Gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

Oude Ophuis, Charlotte M.C.; Koppert, Lisa B.; Monyé, Cécile de; van Deurzen, Carolien H.M.; Koljenović, Senada; van Akkooi, Alexander C.J.; Verhoef, Cornelis; Grünhagen, Dirk J.

doi:10.1186/s12885-017-3236-2

Table 1 Studies of Ultrasound Imaging of Regional Lymph Nodes in Melanoma Patients Scheduled for Sentinel Node Biopsy

From: Gamma probe and ultrasound guided fine needle aspiration cytology of the sentinel node (GULF) trial - overview of the literature, pilot and study protocol

Author, year	Study Design	N	US Setting	FNAC/other technique	Sens (%)	Spec (%)	PPV (%)	NPV (%)
Rossi [61], 2000	Not mentioned	69	Pre-lympho	No	33	100	100	86
Rossi [25], 2003	Prospective, monocentric	125	Pre-lympho	FNAC if US suspicious	US alone: Not mentioned	-	-	-
Rossi [25], 2003	Prospective, monocentric	125	Pre-lympho	FNAC if US suspicious	US-FNAC: 39	100	100	85
Hocevar [62], 2004	Prospective, monocentric	57	unknown	FNAC if US suspicious	US alone: 71	84	59	90
Hocevar [62], 2004	Prospective, monocentric	57	unknown	FNAC if US suspicious	US-FNAC: Not mentioned	-	-	-
Testori [63], 2005	Retrospective, monocentric	88	unknown	No	94	90	64	99
Starritt [64], 2005	Prospective, monocentric	31 all SN +	Post-lympho	No	NA	NA	NA	NA
Voit [65], 2006	Prospective, monocentric	127	Post-lympho	FNAC if US suspicious	US alone: 79	72	53	90
					FNAC alone: 59	100	100	85
					US-FNAC: 82	72	54	91
Van Rijk [26], 2006	Retrospective, monocentric	107	Pre-lympho	FNAC if US suspicious	US alone: 34	87	-	-
Van Rijk [26], 2006	Retrospective, monocentric	107	Pre-lympho	FNAC if US suspicious	US-FNAC: 4.7	100	-	-
Sibon [66], 2007	Prospective, monocentric	131	Pre-lympho	No	9	96	43	-
Kunte [67], 2009	Prospective, monocentric	25	Pre- and post-lympho	No	33	100	100	88
Voit [30], 2009	Prospective, monocentric	400	Post-lympho	FNAC if US suspicious	65	99	93	92
Sanki [60], 2009	Prospective, monocentric	716	Post-lympho	No	33	97	60	88
De Giorgi [36], 2010	Prospective monocentric	15	Post-lympho	Standard CEUS	CEUS: 100	62	55	100
Voit [31], 2010	Prospective monocentric	400	Post lympho	FNAC if US suspicious	All Berlin criteria combined: 82	80	52	94
Hinz [58], 2011	Prospective monocentric	81	Pre and post lympho	No	22	100	100	96
Chai [68], 2012	Retrospective monocentric	325	Pre-lympho	FNAC if US suspicious	34	86	37	84
Marone [69], 2012	Prospective monocentric	623	Pre-lympho	No	15	100	100	87
Pilko [70], 2012	Retrospective Monocentric	405	Pre-lympho	FNAC if US suspicious	Not mentioned	-	-	-
Stoffels [71], 2012	Retrospective Monocentric	221	Pre-lympho	FNAC if US suspicious	14	97	100	97
Hinz [72], 2013	Retrospective Monocentric	20	Pre-lympho &, pre PET-CT	No If US malig. Direct LND	12	100	100	74
Ulrich [73], 2014 In German	Prospective monocentric	800	Post lympho	FNAC if US suspicious	US-FNAC: 56	99	92	89
Voit [32], 2014	Prospective monocentric	1000	Post lympho	FNAC if US suspicious	US alone: 71	-	-	-
Voit [32], 2014	Prospective monocentric	1000	Post lympho	FNAC if US suspicious	US-FNAC: 51	99	99	89
Voit [33], 2016	Prospective monocentric	1000	Post lympho	FNAC if US suspicious	US alone: 71	-	-	-
Voit [33], 2016	Prospective monocentric	1000	Post lympho	FNAC if US suspicious	US-FNAC: 51	99	99	89

Overview of studies reporting on ultrasound imaging of regional lymph nodes in melanoma patients prior to sentinel node biopsy. Abbreviations: US ultrasound, FNAC fine needle aspiration cytology, CEUS contrast enhanced ultrasound, Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, lympho lymphoscintigraphy, NA not applicable

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Cancer

Contact us