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Table 1 Clinical data and ALK results

From: Aberrant expression of ALK and EZH2 in Merkel cell carcinoma

No

MCCa

MCV

age

Tumor location

Tumor size mm

ALK NGSb

ALK IHC D5F3 5A4

ALK FISHc

1

P2

pos

< 80

Right cheek

Ā 

+

+ āˆ’

āˆ’

2

P3

pos

ā‰„ 80

Posterior thigh

85

+

+ āˆ’

+

3

P4

pos

< 80

Thorax

70

+

+ āˆ’

āˆ’

4

P5

pos

< 80

Right knee

12

+

+ āˆ’

Ā 

5

P9

pos

ā‰„ 80

unknown

20

+

+ +

āˆ’

6

N10

neg

ā‰„ 80

Right arm

50

+

+ +

+

7

N11

neg

ā‰„ 80

Left temple

15

āˆ’

ā€“ ā€“

āˆ’

8

P12

pos

ā‰„ 80

Forehead

40

+

+ āˆ’

āˆ’

9

P13

pos

< 80

Right buttock

34

+

+ āˆ’

āˆ’

10

P14

pos

ā‰„ 80

Left cheek

18

+

+ āˆ’

āˆ’

11

N17

neg

< 80

Right cheek

20

+

+ āˆ’

āˆ’

12

N18

neg

< 80

Right breast

20

+

+ āˆ’

Ā 

13

N19

neg

< 80

Calf

13

+

+ āˆ’

Ā 

14

N21

neg

< 80

Neck

25

+

+ āˆ’

ā€“

15

P23

pos

< 80

Left forearm

40

+

+ āˆ’

āˆ’

16

N25

neg

ā‰„ 80

Left back

Ā 

+

+ āˆ’

+

17

P26

pos

ā‰„ 80

Right shoulder

24

+

+ āˆ’

āˆ’

18

P28

pos

ā‰„ 80

Left arm

75

+

āˆ’

Ā 

19

N29

neg

ā‰„ 80

Back

75

āˆ’

ā€“ ā€“

āˆ’

20

N31

neg

< 80

Left foot

10

+

+ +

āˆ’

21

N32

neg

ā‰„ 80

Right breast

23

āˆ’

(+) ā€“

āˆ’

22

N33

neg

ā‰„ 80

Front of left ear

18

āˆ’

(+) ā€“

āˆ’

23

P34

pos

< 80

Flank

20

+

+ +

+

24

N35

neg

< 80

Upper abdomen

25

+

+ āˆ’

āˆ’

25

P36

pos

< 80

Right buttock

30

+

āˆ’

Ā 

26

N37

neg

ā‰„ 80

Right cheek

30

+

+ āˆ’

+

  1. aMCC tumor number. bCases that had high expression of ALK by NGS are marked +. cTumors with 3 or more dual signals in FISH are marked +. In cases N32 and N33, low proportion of tumor cells stained positive with D5F3 and thus are marked (+)