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Table 3 Univariate and multivariate analysis of prognostic variables in 89 cases undergoing radical cystectomy

From: Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder

Variables

Disease-specific survival

Overall survival

Univariate

Multivariate

Univariate

Multivariate

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age at RC

  ≤ 70

1

     

1

     

  > 70

1.9

0.8–4.2

0.12

   

1.7

0.8–3.3

0.15

   

Sex

 Male

1

     

1

     

 Female

1.4

0.5–3.8

0.52

   

1.3

0.5–3.0

0.57

   

Clinical T

 NMIBC

1

  

1

  

1

  

1

  

 T2

3.1

0.2–39.7

0.38

0.8

0.09–7.0

0.84

1.3

0.2–8.2

0.8

1.3

0.2–11.5

0.78

 T3

3.5

0.2–54.0

0.36

0.7

0.08–6.7

0.72

1.1

0.2–9.2

0.9

0.97

0.2–4.9

0.98

 T4

4.0

1.2–13.7

0.03

4.1

0.5–35.4

0.20

3.1

1.1–8.8

0.04

6.7

0.8–56.9

0.08

Clinical N

 N0

1

  

1

  

1

  

1

  

 N+

11.3

2.8–45.7

0.0006

3.1

1.2–7.8

0.02

3.9

1.2–12.5

0.02

1.9

0.8–4.5

0.15

Variant histology

 Negative

1

     

1

     

 Positive

0.9

0.3–2.2

0.76

   

0.9

0.4–1.9

0.73

   

Neoadjuvant chemotherapy

 No

1

     

1

     

 Yes

0.7

0.3–1.5

0.35

   

0.7

0.3–1.5

0.35

   

Adjuvant chemotherapy

 No

1

     

1

     

 Yes

1.8

0.6–5.3

0.28

   

0.7

0.4–1.4

0.72

   

Sarcopenia status

 No

1

  

1

  

1

  

1

  

 Yes

2.7

1.1–7.2

0.048

1.9

0.8–4.5

0.14

2.3

1.1–5.3

0.046

2.2

1.1–4.6

0.03

Psoas major muscle loss

  > −10%

1

  

1

  

1

  

1

  

  ≤ −10%

2.2

0.99–4.8

0.052

2.0

0.9–4.7

0.11

2.2

1.2–4.4

0.02

2.4

1.2–4.9

0.02

  1. HR hazard ratio, CI confidence interval, RC radical cystectomy, NMIBC non-muscle invasive bladder cancer (T1/isolated Tis)
  2. According to the definition for the Martin's definition [21]