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Table 2 PANTHER gene ontology analysis of 132 genes hypermethylated in 100% of CIMP-H tumours

From: Genome-wide methylation analysis identifies a core set of hypermethylated genes in CIMP-H colorectal cancer

PANTHER GO-Slim Biological Process

Expected

Fold enrichment

P value

skeletal system development (GO:0001501)

1.4

14.8

2.88E-15

segment specification (GO:0007379)

1.1

13.9

9.62E-11

muscle organ development (GO:0007517)

1.8

12.7

2.35E-16

pattern specification process (GO:0007389)

1.4

11.4

3.08E-10

mesoderm development (GO:0007498)

3.2

10.1

1.14E-20

ectoderm development (GO:0007398)

3

9

7.94E-16

nervous system development (GO:0007399)

4.9

8.6

1.79E-25

embryo development (GO:0009790)

1.3

8

1.52E-04

system development (GO:0048731)

7

7.3

1.83E-28

heart development (GO:0007507)

1

7

1.71E-02

cellular defense response (GO:0006968)

1.1

6.5

2.78E-02

regulation of transcription from RNA polymerase II promoter (GO:0006357)

7.4

6.4

2.35E-23

transcription from RNA polymerase II promoter (GO:0006366)

9.3

5.2

3.85E-20

developmental process (GO:0032502)

13.2

5

3.25E-29

transcription, DNA-dependent (GO:0006351)

11.5

4.4

6.06E-18

cell differentiation (GO:0030154)

2.8

3.9

3.25E-02

RNA metabolic process (GO:0016070)

15.4

3.2

1.34E-12

nucleobase-containing compound metabolic process (GO:0006139)

23

2.2

1.11E-06

Unclassified (UNCLASSIFIED)

46.5

0.6

0.00E + 00

  1. PANTHER was used to test for over represented gene ontology terms among the 132 genes associated with CpG islands hypermethylated in 100% of CIMP-H tumours. The background gene list was all genes which were tested for differential methylation