Fig. 3
Six1 downregulation results in a growth arrest of Panc1 cells in a xenograft model. a Body weight curve of mice. Straight line: Panc-1 tumours with scramble shRNA (Panc1shCtl). Dashed line: Panc-1 tumours with Six1-shRNA (Panc1shSix1). No difference in body weight in both groups. b Tumour growth curve of Panc-1 tumours. Straight line: Panc-1 tumours with scramble shRNA (Panc1shCtl). Dashed line: Panc-1 tumours with Six1-shRNA (Panc1shSix1). c Tumour volume of Panc-1 tumour after resection from xenograft models. Upper panel: Panc-1 tumours with Six1-shRNA (Panc1shSix1). Lower panel: Panc-1 tumours with scramble shRNA (Panc1shCtl). d Representative figures for expression of Six1 in Panc-1 tumours with scramble shRNA (left panel) and tumours with Six1-shRNA (right panel). e,f Representative figures for expression of CD44 e and CD24 f in Panc-1 tumours with scramble shRNA (left panel) and tumours with Six1-shRNA (right panel)