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Fig. 3 | BMC Cancer

Fig. 3

From: Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

Fig. 3

Kaplan-Meier plot of palpable mammary tumors in congenic rats. Onset of tumors in rats exposed to a MNU at 3 weeks of age, b MNU at 8 weeks of age, and c DMBA at 8 weeks of age. Squares illustrate rapid and circles illustrate slow acetylator Nat2 congenic rats. Rapid acetylator congenic rats had a significantly (p<0.05) shorter latency for development of first palpable mammary tumor compared to slow acetylator congenic rats after MNU administration at either 3 or 8 weeks of age. Similar findings were obtained after DMBA administration at 8 weeks of age although the difference was not significant (p=0.065)

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BMC Cancer

ISSN: 1471-2407

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