Table 2 The TGF-β information and results of the included studies
Gene subtype | High expression (%) | Test sample | Test content | Test method | Analytic method | Outcome | HR for OS | 95% CI HR for OS | HR for DFS | 95% CI HR for DFS | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Zhu J | TGF-β1 | 53.0 | Tissue | Protein | IHC | Multivariate | OS | 3.33 | 1.41–7.87 | NR | NR |
Chun HK | TGF-β1 | 14.9 | Tissue | Protein | IHC | Multivariate | DFS | NR | NR | 9.19 | 1.26–67.20 |
Langenskiöld M | TGF-β1 | NR | Tissue | Protein | ELISA | Multivariate | OS | 1.00 | 0.99–1.01 | NR | NR |
Uhlmann ME | TGF-β | 25.2 | Tissue | mRNA | PCR | Surv curve | OS | 1.13 | 0.42–3.03 | NR | NR |
Lampropoulos P | TGF-β | 71.3 | Tissue | Protein | IHC | Multivariate | OS | 4.68 | 2.09–10.48 | NR | NR |
Li X | TGF-β1 | 70.7 | Tissue | Protein | IHC | Univariate | OS, DFS | 0.75 | 0.48–1.16 | 0.81 | 0.55–1.20 |
Khanh do T | TGF-β1 | 55.3 | Tissue | Protein | IHC | Multivariate | OS, RFS | 1.62 | 0.74–3.56 | 1.46 | 0.74–2.87 |
Wincewicz A | TGF-β1 | 83.3 | Tissue | Protein | IHC | Survival curve | DFS | NR | NR | 1.00 | 0.93–1.07 |
Gulubova M | TGF-β1 | 25.4 | Tissue | Protein | IHC | Surv curve | OS | 1.35 | 0.82–2.23 | NR | NR |
Bellone G | TGF-β1 | NR | Serum | Protein | ELISA | Multivariate | DFS | NR | NR | 1.11 | 1.03–1.20 |
Tsamandas AC | TGF-β1 | 79.0 | Tissue | Protein | IHC | Multivariate | OS, DFS | 1.55 | 1.33–3.08 | 1.09a | 0.27–4.4 |
Robson H | TGF-β1 | 58.3 | Tissue | Protein | IHC | Surv curve | OS | 0.56 | 0.15–2.14 | NR | NR |
Friedman E | TGF-β1 | 58.8 | Tissue | Protein | PCR | Surv curve | DFS | NR | NR | 3.33 | 0.47–23.43 |