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Table 2 Detected EM clusters of Ki-67 values within subgroups of breast cancer patients defined by certain immunohistochemical phenotypes (LMA - low mitotic activity; IMA - intermediate mitotic activity; HMA - high mitotic activity). These are the results of the first stage of EM clustering

From: Distribution of Ki-67 values within HER2 & ER/PgR expression variants of ductal breast cancers as a potential link between IHC features and breast cancer biology

ER/PgR phenotypes

Breast cancer HER2 status

0+

1+

2+

3+

ER + PgR+

Cancer types

Luminal A/B1

Luminal B2

EM clusters

LMA

IMA

LMA

IMA

LMA

IMA

LMA

IMA

Patients

n

255

83

187

46

52

11

139

26

%

75.4

24.6

80.3

19.7

82.5

17.5

84.2

15.0

Mean Ki-67%

9.5

39.1

11.3

39.6

13.5

38.6

19.2

56.6

St.dev. of Ki-67

6.1

15.2

7.2

11.1

6.9

9.5

10.1

10.3

ER + PgR-

Cancer types

Luminal A/B1

Luminal B2

EM clusters

LMA

IMA

LMA

IMA

n/a

LMA

IMA

Patients

n

15

10

20

6

7

31

2

%

60.0

40.0

76.9

23.1

n/a

93.9

6.1

Mean Ki-67%

9.7

42.4

15.5

39.0

25.4

60.0

St.dev. of Ki-67

5.4

14.8

8.6

6.0

13.3

7.1

ER-PgR-

Cancer types

triple-negative

pure HER2

EM clusters

IMA

HMA

IMA

HMA

n/a

IMA

HMA

Patients

n

63

43

29

11

8

111

14

%

59.4

40.6

72.5

27.5

n/a

88.8

11.2

Mean Ki-67%

34.0

79.0

32.3

82.7

32.4

73.2

St.dev. of Ki-67

18.3

6.4

18.1

8.5

14.7

8.7