Patient ID | Identified variant/gene | Metastases | Histologic subtype | Molecular subgroup | Treatment Protocol | Statusa | Rare adverse events grade 4 on chemotherapy | Drug in the regimen during the incidence of rare adverse events grade 4 | The course of chemotherapy |
---|---|---|---|---|---|---|---|---|---|
1. | p.V606I/MSH2 | YES | classic | 4 | HR | ADF | NO | - | - |
2. | p.A733T/MSH2 | YES | LCA | Non-WNT/SHH (3 or 4) | For relapse | DoD | Pneumonia | Irinotecan, Dacarbazine | pre-irradiation chemotherapy |
3. | p.R1093* /RAD50 | NO | classic | 3 | HR | ADF | Central nervous system toxicity | Etoposide, Ifosphamide, Cisplatin | pre-irradiation fourth course of chemotherapy |
4. | p.Lys219fs*19/NBN | YES | classic | 4 | HR | ADF | no data | - | - |
5. b | p.Lys219fs*19/NBN | NO | classic | WNT | HR | ADF | NO | - | - |
6. b | p.Lys219fs*19/NBN | YES | classic | no data | <3 yrs | DoD | Pneumonia | Vincristin, Etoposide, Cisplatin | first course of chemotherapy |
7. | p.Lys219fs*19/NBN | YES | LCA | 4 | HR | DoD | NO but secondary AML M5 4 yrs. after diagnosis | - | - |
8. b | p.Lys219fs*19/NBN | NO | classic | Non-WNT/SHH (3 or 4) | SR | ADF | NO | - | - |
9. | p.Lys219fs*19/NBN | NO | classic | 4 | HR | DoD | NO | - | - |
10. | p.I171V/NBN | YES | classic | 4 | HR | ADF | NO | - | - |
11. | p.I171V/NBN | NO | classic | no data | <3 yrs | DoD | Central nervous system toxicity | Vincristin, Etoposide, Endoksane, Cisplatin | after two courses of chemotherapy |
12. b | p.I171V/NBN | YES | classic | no data | HR | DoD | Colitis with gastrointestinal bleeding/ | Vincristin, Etoposide, Carboplatin | pre-irradiation first course of chemotherapy |
13. | p.I171V/NBN | NO | classic | 4 | HR | ADF | NO | - | - |
14. | p.L694*/FANCM | YES | LCA | 4 | HR | ADF | Central nervous system toxicity | Vincristine, Cisplatin, Lomustin | post radiation chemotherapy |
15. | p.R695C/ERCC2 | NO | classic | Non-WNT/SHH (3 or 4) | SR | ADF | Colitis with gastrointestinal bleeding/ | Vincristine, Etoposide, Carboplatin | pre-irradiation first course of chemotherapy |
16 | p.V738L/EXO1 | NO | classic | 4 | SR | ADF | Enterocolitis | Vincristine, Etoposide, Carboplatin | pre-irradiation first course of chemotherapy |