Table 4 Serum biomarker levels of patients with malignant mesothelioma classified by stage, histology and chemotherapy responses
Classification | Mesothelin (nmol/L) Median (min-max) | Midkine (pg/mL) Median (min-max) |
|---|---|---|
Stage (case number)a | ||
 I (12) | 0.95 (0.30-67.50) | 220.54 (103.95-5508.08) |
 II (11) | 1.20 (0.30-2.80) | 513.61 (103.95-2143.51) |
 III (34) | 1.25 (0.40-21.50) | 644.89 (103.95-17,381.64) |
 IV (36) | 2.90 (0.30-27.40) | 925.17 (103.95-5244.74) |
|  | p = 0.052 | p = 0.059 |
Histology (case number) | ||
 Epitheloid (66) | 2.00 (0.30-67.50) | 623.56 (103.95-17,381.64) |
 Non-epitheloid (23) | 1.20 (0.30-9.0) | 753.50(103.95-5244.74) |
 Undefined (6)b | 1.25 (0.60-7.40) | 768.13 (103.95-1722.46) |
|  | p = 0.033 | p = 0.501 |
Chemotherapy response (case number) | ||
 Progressive disease (16) | 1.75 (0.30-67.50) | 731.47 (103.95-5508.08) |
 Stable disease (17) | 1.70 (0.40-7.70) | 417.94 (103.95-2832.48) |
 Objective response (12) | 2.70 (0.70-21.50) | 441.06 (103.95-17,381.64) |
|  | p = 0.452 | p = 0.669 |