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Table 2 Schedule of study procedures

From: Uniform FDG-PET guided GRAdient Dose prEscription to reduce late Radiation Toxicity (UPGRADE-RT): study protocol for a randomized clinical trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

Procedure

Before treatment

During treatment

Months after treatment

0

3

6

12

24

Planning FDG-PET/CT-scan

x

      

Acute toxicity (CTC v2.0)

 

x

x

x

   

Late toxicity (RTOG-EORTC)

   

x

x

x

x

Assessment of thyroid function

(Blood analysis)

x

   

x

x

x

Dysphagia related quality of life

(PSS-HN, SWAL-QOL)

x

  

x

x

x

x

Assessment of swallowing function

(Water swallowing test)

x

  

x

 

x

x

Xerostomia related quality of life

(GRIX)

x

  

x

x

x

x

Assessment salivary gland function

(sialometry, sialochemistry)

x

  

x

 

x

x

General quality of life

(EORTC QLQ-C30, EORTC H&N35)

x

  

x

x

x

x

Assessment of recurrence

  

each follow-up visit