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The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

  • Ravi S. Narayan1,
  • Carlos A. Fedrigo1,
  • Eelke Brands1,
  • Rogier Dik1,
  • Lukas J.A. Stalpers2,
  • Brigitta G. Baumert3, 4,
  • Ben J. Slotman1,
  • Bart A. Westerman5,
  • Godefridus J. Peters6 and
  • Peter Sminia1Email author
BMC Cancer201717:204

https://doi.org/10.1186/s12885-017-3193-9

Received: 13 October 2016

Accepted: 11 March 2017

Published: 21 March 2017

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Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
13 Oct 2016 Submitted Original manuscript
14 Dec 2016 Reviewed Reviewer Report - Nadia Zaffaroni
20 Dec 2016 Reviewed Reviewer Report - Ratna Vadlamudi
20 Jan 2017 Author responded Author comments - Ravi Narayan
Resubmission - Version 2
20 Jan 2017 Submitted Manuscript version 2
23 Jan 2017 Reviewed Reviewer Report - Ratna Vadlamudi
6 Feb 2017 Reviewed Reviewer Report - Nadia Zaffaroni
21 Feb 2017 Author responded Author comments - Ravi Narayan
Resubmission - Version 3
21 Feb 2017 Submitted Manuscript version 3
3 Mar 2017 Author responded Author comments - Ravi Narayan
Resubmission - Version 4
3 Mar 2017 Submitted Manuscript version 4
Publishing
11 Mar 2017 Editorially accepted
21 Mar 2017 Article published 10.1186/s12885-017-3193-9

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Radiation Oncology, VU University Medical Center/Cancer Center Amsterdam, Amsterdam, The Netherlands
(2)
Department of Radiation Oncology, Academic Medical Center, Amsterdam, The Netherlands
(3)
Clinical Cooperation Unit Neurooncology, MediClin Robert Janker Klinik & University of Bonn Medical Center, Bonn, Germany
(4)
Department of Radiation Oncology, Maastro Clinic, Maastricht, The Netherlands
(5)
Department of Neurosurgery, Neuro Oncology Research Group, VU University Medical Center, Amsterdam, The Netherlands
(6)
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

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