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Fig. 2 | BMC Cancer

Fig. 2

From: The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

Fig. 2

Low dose MK2206 sensitizes long-term U87MG multi-cellular spheroid cultures to irradiation and temozolomide. a U87 multicellular spheroids were treated for 15 days with 1 μM or 10 μM MK2206. Data points represent means, ±SD (n = 8 spheroids). b-c U87 spheroids were treated for 15 days with 1 μM MK2206 together with fractions of 5 μM TMZ or 2 Gy irradiation. Points are means, ±SD (n = 8 spheroids). d Combination index for all combinations of MK/TMZ/RT for each time point. CI < 1 indicates synergy, CI > 1 indicates antagonism. e U87 spheroids were treated with 1 μM MK and/or with 4 Gy irradiation and lysed at indicated time points

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BMC Cancer

ISSN: 1471-2407

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