Morphological and phenotypical features of ovarian metastases in breast cancer patients

BMC Cancer

Table 3 Immunohistochemical expression of the investigated markers in invasive breast tumors and their corresponding ovarian metastases

Marker	% of positive tumor cells in invasive ductal carcinoma				% of positive tumor cells in invasive lobular carcinoma				% of positive tumor cells in invasive ductolobular carcinoma
	Breast tumors (n = 44)		Ovarian metastases (n = 58)		Breast tumors (n = 7)		Ovarian metastases (n = 10)		Breast tumors (n = 7)		Ovarian metastases (n = 7)
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
E-cadherin	91	18	91	20	9	23	0	0	73	35	51	41
EMA	86	23	84	24	86	32	64	32	97	6	99	2
Her2/neu	76	35	81	31	88	26	74	26	80	34	67	38
CEA	56	40	57	39	73	32	59	26	62	32	56	33
αvβ6 integrin	51	40	45	39	54	35	38	28	45	30	29	35
EpCAM	36	42	38	39	38	46	68	26	19	29	35	29
SD = standard deviation

The mean percentages of immunohistochemically positive stained tumor cells are subdivided by histological subtype. Tumor cell membranes were considered positive if they showed immunoreactivity of any intensity. EMA, epithelial membrane antigen; Her2/neu, human epidermal growth receptor type 2; CEA, carcinoembryonic antigen; EpCAM, epithelial cell adhesion molecule

ISSN: 1471-2407