Morphological and phenotypical features of ovarian metastases in breast cancer patients

BMC Cancer

Table 1 Clinicopathological characteristics of patients with primary invasive breast cancer and ovarian metastases

Clinicopathological characteristics	N = 46	%
Age at diagnosis of breast cancer, years - median (range)	36.5 (28–40)	-
BRCA gene mutation
No	8	17.4
Yes, BRCA 1	1	2.2
Yes, BRCA 2	0	0.0
Unknown	37	80.4
Breast tumor localization
Left	23	50.0
Right	21	45.7
Both	2	4.3
Most extensively performed breast surgery
Needle biopsy	4	8.7
Breast conserving surgery	15	32.6
Mastectomy	27	58.7
Breast tumor histological subtype
Ductal	36	78.2
Lobular	5	10.9
Ductolobular	5	10.9
Scarff-Bloom-Richardson grade
I	4	8.7
II	19	41.3
III	15	32.6
Unknown	8	17.4
Estrogen receptor
Negative	5	10.9
Positive	41	89.1
Progesterone receptor
Negative	8	17.4
Positive	38	82.6
Her2/neu receptor
Negative	38	82.6
Positive	8	17.4
Tumor stage
T1	11	23.9
T2	24	52.2
T3	7	15.2
T4	4	8.7
Nodal stage
N0	14	30.4
N1	12	26.1
N2	10	21.7
N3	10	21.7
Distant metastasis
cM0	39	84.8
cM1	7	15.2
Age at diagnosis of ovarian metastases, years - median (range)	40.0 (31–51)	-
Time between breast cancer and ovarian metastases, months - median (range)	41.9 (0.3–141.8)	-
Recurrent disease prior to oophorectomy
No	15	32.6
Yes, locoregional recurrence	12	26.1
Yes, distant recurrence	19	41.3
Type of ovarian surgery
Unilateral oophorectomy	0	0.0
Bilateral oophorectomy	46	100.0
Indication for oophorectomy
Prophylactic because of breast cancer	9	19.6
Therapeutic because of breast cancer	25	54.3
Abnormal ovaries on ultrasound	12	26.1
Localization of ovarian metastases
Left	4	8.7
Right	6	13.0
Both	29	63.0
Unknown	7	15.2

ISSN: 1471-2407