Protocol of the PANCALYZE trial: a multicenter, prospective study investigating the tumor biomarkers CXCR4, SMAD4, SOX9 and IFIT3 in patients with resected pancreatic adenocarcinoma to predict the pattern of recurrence of the disease

Table 2 Schedule of enrolment, interventions and assessments (the responsible person is stated in brackets). As resectability of the tumor is a prerequisite to obtain tissue samples, the day of surgery (day 0) is the time point of allocation. Day of discharge (dis). Month (m)

	STUDY PERIOD
	Enrolment	Allocation	Post-allocation					Close-out
TIMEPOINT	until − 1	0	0	dis	6 m	12 m	18 m	24 m
ENROLMENT:
Eligibility screen (surgeon)	X
Informed consent (surgeon)	X
Allocation (surgeon)		X
INTERVENTIONS:
Take 15 ml blood sample (surgeon)			X
Prepare tumor tissue samples (pathologist)			X
ASSESSMENTS:
Diagnosis of PDAC (surgeon)	X
Demographic data, operation procedure, complications				X
Recurrence pattern, survival time, adjuvant tumor therapy and hospital admissions					X	X	X	X

ISSN: 1471-2407