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Fig. 8 | BMC Cancer

Fig. 8

From: Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells

Fig. 8

Validation of CELx HSF test in patient tissue specimen-derived primary cells ex vivo. Primary epithelial cells derived from two HER2- (R39 and R49) patients with breast cancer and one healthy control subject (R62) were subjected to CELx HSF tests. Responses of NRG1b-driven HER2 CELx signals with and without pertuzumab for these primary cells are plotted along with those for the HER2+ reference cell line (SKBr3) and the HER2- reference cell line (MDA-MB231) as bar charts. Black bars, cells stimulated with NRG1b; Grey bars, cells stimulated with NRG1b in the presence of pertuzumab. HER2- Patient R39 has approximately 80% of the NRG1 CELx signal of HER2+ cell line SKBr3

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