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Table 3 Comparison of ROC areas among the combination of 3 biomarkers

From: Receiver operating characteristic analysis of prediction for gastric cancer development using serum pepsinogen and Helicobacter pylori antibody tests

HP antibody values   PG I/II = 3.0 PG I/II = 2.5
  PGI = 70 PGI = 65 PGI = 70 PGI = 65
1 ROC area 0.619 ± 0.014 0.623 ± 0.014 0.623 ± 0.015 0.625 ± 0.015
(95% CI) (0.591–0.646) (0.595–0.650) (0.594–0.653) (0.596–0.655)
Sensitivity 99.4 100 99.8 99.8
Specificity 8.7 4.4 4.6 4.6
3 ROC area 0.620 ± 0.014 0.624 ± 0.014 0.630 ± 0.015 0.632 ± 0.015
(95% CI) (0.591–0.648) (0.596–0.652) (0.600–0.660) (0.602–0.662)
Sensitivity 99.0 99.2 98.6 98.6
Specificity 11.9 11.9 12.7 12.7
5 ROC area 0.619 ± 0.015 0.624 ± 0.014 0.633 ± 0.016 0.635 ± 0.016
(95% CI) (0.591–0.648) (0.595–0.652) (0.603–0.665) (0.605–0.666)
Sensitivity 98.4 98.4 97.8 97.8
Specificity 16.9 16.9 17.9 17.7
7 ROC area 0.621 ± 0.015 0.625 ± 0.015 0.634 ± 0.016 0.637 ± 0.016
(95% CI) (0.593–0.650) (0.597–0.654) (0.604–0.664) (0.606–0.667)
Sensitivity 97.4 97.4 96.6 96.6
Specificity 19.1 19.1 20.1 20.1
10 ROC area 0.622 ± 0.015 0.626 ± 0.015 0.636 ± 0.016 0.638 ± 0.016
(95% CI) (0.593–0.651) (0.597–0.655) (0.605–0.667) (0.607–0.669)
Sensitivity 97.2 97.2 96.4 96.4
Specificity 21.1 21.1 22.1 22.1
  1. HP Helicobacter pylori, PG pepsinogen, ROC receiver operating characteristic, CI confidence interval
  2. Negative cases were determined when the HP antibody level was below the defined value and the serum PG level was above the defined value of PG I/II or PG I