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Table 2 Comparison of ROC areas among the combination of 2 biomarkers

From: Receiver operating characteristic analysis of prediction for gastric cancer development using serum pepsinogen and Helicobacter pylori antibody tests

PG I/II   PG I PG II HP
2.5 ROC area 0.627 ± 0.017 0.619 ± 0.017 0.605 ± 0.018
(95% CI) (0.594–0.661) (0.585–0.652) (0.571–0.639)
Optimal cut-off point 65/60 50 5
Optimal sensitivity 70.2/69.8 71.2 70.8
Optimal specificity 53.7/54.1 52.5 54.3
3.0 ROC area 0.638 ± 0.017 0.618 ± 0.017 0.594 ± 0.018
(95% CI) (0.604–0.672) (0.604–0.672) (0.558–0.629)
Optimal cut-off point 65 50 5.0/6.0
Optimal sensitivity 81.9 83.9 82.9/82.7
Optimal specificity 42.1 39.8 42.5/42.7
3.5 ROC area 0.631 ± 0.018 0.618 ± 0.017 0.584 ± 0.082
(95% CI) (0.597–0.665) (0.604–0.672) (0.548–0.620)
Optimal cut-off point 65 50 5.0/6.0
Optimal sensitivity 88.9 91.0 89.9/89.5
Optimal specificity 31.6 29.2 33.8/34.2
  1. HP Helicobacter pylori, PG pepsinogen, ROC receiver operating characteristic, CI confidence interval