Receiver operating characteristic analysis of prediction for gastric cancer development using serum pepsinogen and Helicobacter pylori antibody tests

Table 2 Comparison of ROC areas among the combination of 2 biomarkers

PG I/II		PG I	PG II	HP
2.5	ROC area	0.627 ± 0.017	0.619 ± 0.017	0.605 ± 0.018
	(95% CI)	(0.594–0.661)	(0.585–0.652)	(0.571–0.639)
	Optimal cut-off point	65/60	50	5
	Optimal sensitivity	70.2/69.8	71.2	70.8
	Optimal specificity	53.7/54.1	52.5	54.3
3.0	ROC area	0.638 ± 0.017	0.618 ± 0.017	0.594 ± 0.018
	(95% CI)	(0.604–0.672)	(0.604–0.672)	(0.558–0.629)
	Optimal cut-off point	65	50	5.0/6.0
	Optimal sensitivity	81.9	83.9	82.9/82.7
	Optimal specificity	42.1	39.8	42.5/42.7
3.5	ROC area	0.631 ± 0.018	0.618 ± 0.017	0.584 ± 0.082
	(95% CI)	(0.597–0.665)	(0.604–0.672)	(0.548–0.620)
	Optimal cut-off point	65	50	5.0/6.0
	Optimal sensitivity	88.9	91.0	89.9/89.5
	Optimal specificity	31.6	29.2	33.8/34.2

HP Helicobacter pylori, PG pepsinogen, ROC receiver operating characteristic, CI confidence interval

ISSN: 1471-2407