Patients with pathological stage N2 rectal cancer treated with early adjuvant chemotherapy have a lower treatment failure rate

Table 4 Multivariate analysis of prognostic factors for 114 patients with stage N2 rectal cancer

Endpoint	Item	HR	95% CI	p
OS	Lymphovascular invasion (Yes vs No)	3.376	1.043-10.929	0.042
OS	Tumor deposits (Yes vs No)	4.604	1.516-13.976	0.007
DFS	Age (years)	0.961	0.929-0.995	0.026
	A-CT vs. A-CRT	0.345	0.137-0.868	0.024
	Lymphovascular invasion (Yes vs No)	3.324	1.520-7.269	0.003
DMFS	A-CT vs. A-CRT	0.366	0.143-0.938	0.036
	Lymphovascular invasion (Yes vs No)	2.928	1.359-6.309	0.006
	Number of nodes retrieved	0.945	0.897-0.997	0.037

Abbreviations: OS overall survival, DFS disease-free survival, DMFS distant metastasis-free survival, A-CRT primary adjuvant concurrent chemoradiotherapy, A-CT primary adjuvant chemotherapy, HR hazard ratio, CI confidence interval

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