Patients with pathological stage N2 rectal cancer treated with early adjuvant chemotherapy have a lower treatment failure rate

Table 3 Univariate analysis of prognostic factors for 114 patients with stage N2 rectal cancer

Item	n	3y-OS		3y-DFS		3y-LRFS		3y-DMFS
Item	n	%	P	%	P	%	P	%	P
Sex
Men	73	86.0	0.983	75.1	0.831	95.3	0.980	73.9	0.970
Women	41	82.8		68.7		93.9		74.7
Age(years)
<60	91	86.5	0.533	71.1	0.280	95.2	0.943	73.0	0.321
≥ 60	23	75.5		75.2		92.3		75.2
Distance from anal verge (cm)
≤ 5	36	81.8	0.884	65.0	0.247	92.5	0.756	68.0	0.364
> 5	78	85.7		75.9		96.0		76.8
pT category
T2	7	100.0	0.223	68.6	0.908	100.0	0.744	68.6	0.892
T3	96	85.5		71.6		94.2		73.4
T4	11	60.6		85.7		100.0		85.7
TNM stage
IIIB	55	88.6	0.262	72.9	0.675	97.4	0.143	71.4	0.845
IIIC	59	81.2		72.2		92.3		76.8
Lymphovascular invasion
No	86	85.8	0.124	78.2	0.013	93.4	0.819	80.2	0.027
Yes	28	82.2		54.8		100.0		54.8
Tumor deposits
No	91	88.7	0.008	75.3	0.258	96.4	0.190	74.3	0.517
Yes	23	71.3		61.3		88.4		72.8
Number of nodes retrieved
<12	10	77.8	0.066	36.0	0.002	100.0	0.446	36.0	0.001
≥ 12	104	85.2		76.5		94.3		78.2
Sequence
A-CRT	71	81.8	0.379	66.7	0.153	93.7	0.629	67.5	0.074
A-CT	43	90.8		83.9		97.4		86.6

Abbreviations: OS overall survival, DFS disease-free survival, DMFS distant metastasis-free survival, A-CRT primary adjuvant concurrent chemoradiotherapy, A-CT primary adjuvant chemotherapy

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