Fig. 1

Immune responsiveness of woodchucks with increasing viral loads following a single IV dose of JVRS-100. Fold increase in mRNA expression of cytokines and T cell surface markers in peripheral blood following a single IV dose of JVRS-100 at a concentration of 50 or 100 μg/animal into woodchucks with low (n = 2) versus high (n = 2) serum WHV DNA loads. Results are presented as a change from the transcription level observed in control woodchucks with comparable low (n = 2) or high (n = 2) viral loads following a single IV dose of placebo. Vertical lines denote standard deviations