Table 1 Drugs, doses and therapeutic regimens applied in the presented studies
From: The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice
Experimental model | Drug | Route of administration | Dose | Treatment regimen |
|---|---|---|---|---|
Spontaneous tumor formation (Fig. 1) | 1-MNA | per os in drinking water | 100 mg/kg/day | continuously from the age of 8 to 12 weeks to the day of the necropsy |
1,4-DMP | per os in drinking water | 100Â mg/kg/day | continuously from the age of 8 to 12Â weeks to the day of the necropsy | |
PC-3 M-luc2 tumors (Fig. 2) | 1,4-DMP | per os in drinking water | 100 mg/kg/day | continuously from the day 1 to the end of the experiment |
DTX | intraperitoneally | 10Â mg/kg | 2 doses at days 15 and 22 |