Fig. 1
From: The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice
The influence of 1,4-DMP and 1-MNA on the development and the progression of prostate cancer. a The onset of the prostate gland lesions; b survival of the TRAMP mice continuously treated with 1-MNA and 1,4-DMP. c Summarized results of the frequency of the neoplasia, adenocarcinomas and metastases in TRAMP mice determined by the means of histopathological analysis of the tissues isolated during the necropsy. d Images of primary tumors (neoplasia and adenocarcinomas) identified in non-treated and drug-receiving animals and of the metastases localized in lungs of the control animals, kidney of the animal treated with 1-MNA, or liver of the mouse receiving 1,4-DMP. Results of the morphological analysis carried out on blood samples collected during the necropsy of the animals: e platelet count; f mean platelet volume (MPV); g platelet distribution width (PDW); h lymphocyte count; i monocyte count; and j granulocyte count. Plasma concentrations of k TXB2, l 6-keto-PGF1α, m vWF, n soluble P-selectin determined by ELISA. All data are presented as mean ± SD