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Fig. 7 | BMC Cancer

Fig. 7

From: Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5

Fig. 7

Schematic diagram of the mechanism for CPA enhancement of TRAIL induced apoptosis in prostate cancer cells. CPA treatment induces CHOP protein expression via ER stress response pathways. CHOP protein binds to the promoter region of DR5 gene and up-regulates DR5 mRNA and protein expression. Up-regulated DR5 protein arguments TRAIL induced Bid-dependent apoptotic pathways in prostate cancer cells

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BMC Cancer

ISSN: 1471-2407

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