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Fig. 5 | BMC Cancer

Fig. 5

From: A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis

Fig. 5

FOXO1 silencing releases DKK3-mediated block of cell migration. Cells were treated with scrambled negative siRNA (Neg.) or FOXO1 siRNA (Si-RNA) for 24 h, trypsinized, and allowed to migrate for 4 h through modified Boyden chamber. Migrated cells were fixed, stained, and counted manually. Total number of SW-Neo cells treated with scrambled siRNA normalized to 100%, and relative change in migration of SW-Neo and SW-DKK3 cells treated with FOXO1 siRNA is shown in overlapping line graph on left Y-axis. Relative FOXO1 expression in SW-Neo and SW-DKK3 cells treated with FOXO1 siRNA, normalized to FOXO1 expression in SW-Neo cells treated with scrambled siRNA set at 100 shown as bars on right Y-axis

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