Table 1 Summary of custom Ampliseq gene panel for melanoma, including common driver mutations in BRAF, KRAS, NRAS, MEK, GNAQ, and GNA11
From: Validation of an NGS mutation detection panel for melanoma
Gene | Reference | Codons included | Number of Mutations |
|---|---|---|---|
BRAF | NM_004333.4 | 466, 469, 583, 584, 586, 592, 594, 595, 597, 600, 601, 605, 614, 618 | 29 |
GNAQ | NM_002072.3 | 209, 359 | 6 |
GNA11 | NM_002067.2 | 183, 209, 223 | 3 |
NRAS | NM_002524.4 | 12, 13, 18, 50, 59, 61, 68 | 7 |
c-KIT | NM_000222.2 | 553, 557, 559, 560, 566, 569, 576, 642, 655, 816, 820, 822, 823, 829, 853 | 18 |
KRAS | NM_033360 | 12, 61 | 5 |
MEK1/MAP2K1 | NM_002755.2 | 111, 124, 203, 264 | 5 |