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Table 4 Differences from baseline values at T1 and T2

From: Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancer-related fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design

  Aerobic therapy Multimodal therapy p Combination therapy p
CFS-D total score
 T1.10-T0.01 −6.3 (7.4) −8.9 (7.1) 0.053 −7.9 (9.0) 0.285
 T2-T0.01 −3.4 (9.1) −9.1 (7.9) †† 0.004 −7.3 (10.2) 0.111
PSQI total score
 T1.10-T0.01 −1.0 (1.8) −2.9 (2.9) †† 0.044 −2.5 (3.4) 0.077
 T2-T0.01 −0.3 (2.8) −2.4 (4.0) 0.047 −3.1 (3.2) 0.007
CFS-D physical
 T1.10-T0.01 −3.2 (3.8) −3.7 (3.5) 0.359 −3.2 (4.2) 0.777
 T2-T0.01 −0.9 (4.1) −4.1 (4.2) †† 0.003 −3.1 (4.6) 0.075
CFS-D cognitive
 T1.10-T0.01 −2.0 (2.3) −3.0 (3.1) 0.062 −2.5 (3.1) 0.556
 T2-T0.01 −2.0 (3.6) −2.9 (3.2) 0.055 −2.6 (3.7) 0.431
CFS-D affective
 T1.10-T0.01 −1.1 (1.9) −2.2 (2.0) †† 0.004 −2.2 (2.6) 0.018
 T2-T0.01 −0.5 (2.1) −2.2 (1.7) ††† 0.004 −1.6 (3.4) 0.079
PSQI subjective sleep quality
 T1.10-T0.01 −0.5 (0.5) −0.6 (0.6) 0.842 −0.5 (0.8) 0.757
 T2-T0.01 −0.1 (0.7) −0.6 (0.8) 0.054 −0.7 (0.7) 0.041
PSQI sleep latency
 T1.10-T0.01 0.0 (0.8) −0.7 (0.9) †† 0.004 −0.3 (0.8) 0.066
 T2-T0.01 0.1 (0.8) −0.4 (1.0) 0.155 −0.4 (1.1) 0.0296
PSQI sleep duration
 T1.10-T0.01 −0.5 (0.7) −0.2 (0.8) 0.497 −0.2 (1.0) 0.517
 T2-T0.01 −0.1 (0.6) −0.4 (1.2) 0.226 −0.6 (1.1) 0.036
PSQI sleep efficiency
 T1.10-T0.01 −0.3 (0.8) −0.7 (1.3) 0.258 −0.6 (1.1) 0.335
 T2-T0.01 0.1 (1.0) −0.3 (1.3) 0.759 −0.7 (1.1) 0.0597
PSQI sleep disturbances
 T1.10-T0.01 −0.1 (0.3) −0.3 (0.6) 0.411 −0.2 (0.6) 0.463
 T2-T0.01 −0.1 (0.6) −0.3 (0.6) 0.2497 −0.1 (0.7) 0.397
PSQI taking hypnotics
 T1.10-T0.01 0.3 (0.9) −0.1 (0.5) 0.109 −0.1 (0.6) 0.109
 T2-T0.01 −0.1 (0.9) 0.1 (0.6) 0.398 −0.1 (0.6) 0.637
PSQI daytime sleepiness
 T1.10-T0.01 −0.3 (0.8) −0.5 (0.7) 0.066 −0.5 (0.6) 0.326
 T2-T0.01 −0.2 (0.7) −0.5 (0.8) †† 0.024 −0.5 (0.8) 0.180
  1. p-value for test for superiority vs. aerobic therapy
  2. test for non-inferiority vs. aerobic therapy
  3. Mean (SD); p < 0.05, †† p < 0.01; ††† p < 0.001