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Table 1 Exclusion criteria

From: Impact of a combined multimodal-aerobic and multimodal intervention compared to standard aerobic treatment in breast cancer survivors with chronic cancer-related fatigue - results of a three-armed pragmatic trial in a comprehensive cohort design

• metastases,
• (radio-)chemotherapy or surgery in the last 6 months,
• anemia (hemoglobin <10 mg/dl),
• other severe chronic conditions:
 - heart insufficiency > NYHA 1°,
 - instable angina pectoris > NYHA 1,
 - peripheral arterial occlusive disease > stage 1,
 - COPD > stage 2,
 - chronic renal insufficiency (creatinine > 2,5 mg/dl),
 - manifest non-treated hypothyreosis (TSH > 4 mU/l, fT4 < 9 pmol/l) or hyperthyreosis (TSH <4 mU/l, fT4 > 24 pmol/l),
 - severe limitations of musculoskeletal system,
 - manifest major-depression or psychosis,
 - sleep-disorders such as untreated sleep apnea syndrome,
 - untreated relevant restless legs-syndrome or narcolepsy,
• ongoing erythropoietin-therapy or transfusions,
• intensive training with optimized physical training of more than 2 × 30 min per week,
• psychotherapy started within the last 3 months or specified CRF-education or sleep education within the last year.