Fig. 4

Expression of p53, MET or p21 does not correlate with SOCS1 staining in PCa. Representative immunohistochemical staining intensities of p53 (a), MET (b) and p21 (c) in normal prostatic epithelium and representative PCa specimens. The H-score of IHC staining intensity and the ISUP grade groups are indicated for each specimen. d Occasional staining of cyst-like structures by the anti-MET antibody. e Distribution of the H-scores of p53, MET and p21 across the ISUP grade groups. Slope represents the correlation between the H-score and the ISUP grade groups. Statistical analyses between grade groups were carried out using one-way ANOVA adjusted with Kruskal-Wallis multiple comparisons test, and the significant p values are indicated. f Correlation between the staining intensities of SOCS1 and that of p53, MET or p21. Spearman’s rank correlation coefficient (ρ) and its statistical significance (p) are indicated for E and F