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Fig. 8 | BMC Cancer

Fig. 8

From: Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J

Fig. 8

Overexpression of miR-146a enhanced the sensitivity to DDP in A549/DDP cells in vivo. a Growth curve of tumor volumes and tumor images of A549, A549/DDP/NC and A549/DDP/miR-146a. Each data point represents the mean ± SD of 8 mice. Quantification of miR-146a (b) and CCNJ mRNA levels (c) in the transplanted tumor tissues among A549, A549/DDP/NC and A549/DDP/miR-146a by RT-PCR; (d) The quantification of CCNJ, P-gp, MRP1, LRP, P53 and cleaved caspase-3 in A549, A549/DDP/NC and A549/DDP/miR-146a forming tumor by Western blot. e H&E (upper) and CCNJ (lower) stained sections of the transplanted tumors by IHC, magnification, 40×, Bars = 50 μm. f The quantification of apoptotic cell among A549, A549/DDP/NC and A549/DDP/miR-146a tumor tissues by TUNEL assay. All data were represented as mean value ± SD from 3 independent experiments. **p < 0.01, ***p < 0.001

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