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Table 4 Univariate and multivariate analyses for variables considered for disease-free survival (DFS) (Cox proportional hazard regression model) (n = 541)

From: The C-reactive protein/albumin ratio, a validated prognostic score, predicts outcome of surgical renal cell carcinoma patients

 

DFS Univariate analysis

DFS Multivariate analysis

Characteristics

95% CIs

HR

P value

95% CIs

HR

P value

Age (years)

1.02 to 1.05

1.03

0.002a

1.01 to 1.06

1.03

<0.001b

BMI

0.79 to 0.93

0.86

<0.001a

0.82 to 0.97

0.89

0.005b

Gender

      

 Male

 

1.00(ref.)

    

 Female

0.57 to 1.66

0.97

0.921a

   

Pathological types

      

 Clear cell carcinoma

 

1.00(ref.)

  

1.00(ref.)

 

 Papillary carcinoma

1.15 to 4.80

2.35

0.019a

0.62 to 2.99

1.47

0.431b

 Others

0.33 to 1.80

0.77

0.550a

0.32 to 1.91

0.78

0.587b

Fuhrman-grade

      

 I

 

1.00(ref.)

    

 II

0.62 to 2.68

1.28

0.504a

   

 III

1.01 to 5.86

2.44

0.047a

   

 IV

0.97 to 20.24

4.99

0.055a

   

 unknown

0.68 to 3.40

1.53

0.299a

   

pTNM stage

 I

 

1.00(ref.)

    

 II

1.33 to 4.84

2.54

0.005a

   

 III

3.54 to 11.08

6.26

<0.001a

   

pT status

 T1

 

1.00(ref.)

  

1.00(ref.)

 

 T2

1.57 to 5.03

2.81

<0.001a

1.29 to 4.35

2.38

0.005b

 T3

2.20 to 8.03

4.20

<0.001a

0.65 to 2.72

1.33

0.437b

pN status

 N0

 

1.00(ref.)

  

1.00(ref.)

 

 N1

3.72 to 13.73

7.15

<0.001a

2.19 to 10.09

4.70

<0.001b

Urine protein

      

 No

 

1.00(ref.)

    

 Yes

0.44 to 3.40

1.23

0.691a

   

 Unknown

0.28 to 1.49

0.64

0.301a

   

ALP

      

 Normal

 

1.00(ref.)

    

 Elevated

0.19 to 2.02

0.63

0.440a

   

LDH

 Normal

 

1.00(ref.)

    

 Elevated

0.84 to 2.69

1.51

0.168a

   

CRE

 Normal

 

1.00(ref.)

    

 Elevated

0.59 to 4.51

1.64

0.341a

   

UA

 Normal

 

1.00(ref.)

    

 Elevated

0.44 to 1.69

0.86

0.654a

   

Total protein

 Normal

 

1.00(ref.)

    

 Elevated

0.37 to 1.97

0.85

0.704a

   

Serum globulin

 Normal

 

1.00(ref.)

  

1.00(ref.)

 

 Elevated

1.26 to 3.40

2.07

0.004a

0.69 to 2.05

1.19

0.533b

NLR

 < 1.85

 

1.00(ref.)

  

1.00(ref.)

 

  ≥ 1.85

2.06 to 7.58

3.95

<0.001a

0.78 to 3.37

1.62

0.193b

PLR

 < 153

 

1.00(ref.)

  

1.00(ref.)

 

  ≥ 153

2.54 to 6.92

4.19

<0.001a

1.38 to 4.32

2.44

0.002b

CRP/Alb

 < 0.08

 

1.00(ref.)

  

1.00(ref.)

 

  ≥ 0.08

2.54 to 7.02

4.22

<0.001a

1.22 to 3.75

2.14

0.008b

  1. Abbreviation: HR hazard ratio, CIs confidence intervals, BMI body mass index, pTNM pathologic tumor–node–metastasis, ALP alkaline phosphatase, LDH lactate dehydrogenase, CRE serum creatinine, UA uric acid, LDH lactate dehydrogenase , NLR neutrophil count to lymphocyte count, PLR platelet count to lymphocyte count, CRP/Alb the serum CRP level to the serum Alb level
  2. aUnivariate Cox proportional hazard regression
  3. bMultivariate Cox proportional hazard regression