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Table 3 Univariate and multivariate analyses for variables considered for overall survival (OS) (Cox proportional hazard regression model) (n = 570)

From: The C-reactive protein/albumin ratio, a validated prognostic score, predicts outcome of surgical renal cell carcinoma patients

 

OS Univariate analysis

OS Multivariate analysis

Characteristics

95% CIs

HR

P value

95% CIs

HR

P value

Age (years)

1.01 to 1.05

1.03

<0.001a

1.01 to 1.05

1.03

<0.001b

BMI

0.82 to 0.93

0.87

<0.001a

0.84 to 0.97

0.91

0.007b

Gender

 Male

 

1.00(ref.)

    

 Female

0.73 to 1.82

1.16

0.532a

   

Pathological types

 Clear cell carcinoma

 

1.00(ref.)

  

1.00(ref.)

 

 Papillary carcinoma

1.36 to 4.72

2.53

0.003a

0.67 to 4.39

1.72

0.258b

 Others

0.70 to 2.42

1.30

0.414a

0.64 to 3.99

1.60

0.312b

Fuhrman-grade

 I

 

1.00(ref.)

  

1.00(ref.)

 

 II

0.68 to 2.82

1.39

0.365a

0.72 to 3.21

1.52

0.269b

 III

1.46 to 7.14

3.23

0.004a

0.57 to 3.09

1.33

0.507b

 IV

1.70 to 22.12

6.14

0.006a

0.43 to 6.08

1.62

0.474b

 unknown

1.25 to 5.19

2.55

0.010a

0.43 to 2.55

1.05

0.922b

pTNM stage

 I

 

1.00(ref.)

    

 II

1.27 to 4.85

2.48

0.008a

   

 III

3.51 to 11.40

6.33

<0.001a

   

 IV

14.54 to 46.54

26.01

<0.001a

   

pT status

 T1

 

1.00(ref.)

  

1.00(ref.)

 

 T2

1.76 to 5.46

3.10

<0.001a

1.20 to 3.90

2.16

0.011b

 T3+ T4

4.72 to 12.92

7.81

<0.001a

0.91 to 3.13

1.69

0.098b

pN status

 N0

 

1.00(ref.)

  

1.00(ref.)

 

 N1

6.42 to 17.09

10.47

<0.001a

1.91 to 6.85

3.62

<0.001b

pM status

 M0

 

1.00(ref.)

  

1.00(ref.)

 

 M1

8.71 to 26.12

15.08

<0.001a

1.57 to 6.19

3.12

0.001b

Urine protein

 No

 

1.00(ref.)

    

 Yes

0.46 to 2.84

1.14

0.773a

   

 Unknown

0.48 to 1.74

0.92

0.787a

   

ALP

 Normal

 

1.00(ref.)

    

 Elevated

0.61 to 2.63

1.27

0.527a

   

LDH

 Normal

 

1.00(ref.)

    

 Elevated

0.84 to 2.34

1.40

0.203a

   

CRE

 Normal

 

1.00(ref.)

    

 Elevated

0.78 to 4.07

1.78

0.175a

   

UA

 Normal

 

1.00(ref.)

    

 Elevated

0.77 to 4.08

1.78

0.176a

   

Total protein

      

 Normal

 

1.00(ref.)

    

 Elevated

0.77 to 2.54

1.40

0.265a

   

Serum globulin

 Normal

 

1.00(ref.)

  

1.00(ref.)

 

 Elevated

1.66 to 4.03

2.59

<0.001a

0.84 to2.31

1.39

0.203b

NLR

      

 < 1.85

 

1.00(ref.)

  

1.00(ref.)

 

  ≥ 1.85

3.08 to 11.59

5.97

<0.001a

0.97 to 4.32

2.05

0.060b

PLR

 < 153

 

1.00(ref.)

  

1.00(ref.)

 

  ≥ 153

3.49 to 8.56

5.46

<0.001a

1.43 to 4.07

2.42

<0.001b

CRP/Alb

 < 0.08

 

1.00(ref.)

  

1.00(ref.)

 

  ≥ 0.08

3.48 to 8.86

5.55

<0.001a

1.12 to 3.36

1.94

0.018b

  1. Abbreviation: HR hazard ratio, CIs confidence intervals, BMI body mass index, pTNM pathologic tumor–node–metastasis, ALP alkaline phosphatase, LDH lactate dehydrogenase, CRE, serum creatinine, UA, uric acid, LDH lactate dehydrogenase, NLR neutrophil count to lymphocyte count, PLR platelet count to lymphocyte count, CRP/Alb the serum CRP level to the serum Alb level
  2. aUnivariate Cox proportional hazard regression
  3. bMultivariate Cox proportional hazard regression
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