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Fig. 3 | BMC Cancer

Fig. 3

From: WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice

Fig. 3

Cell proliferation and TUNEL analysis of Wdr13 +/0 and Wdr13 -/0 mice colon. a BrdU immunohistochemistry for BrdU positive cells on representative colonic crypts of mice with indicated genotype and treatment. Black bar, Wdr13 +/0 mice (n = 34); white bar, Wdr13 -/0 mice (n = 31); Dark grey bar, AOM/DSS-treated Wdr13 +/0 mice (n = 28); Light grey bar, AOM/DSS-treated Wdr13 -/0 mice (n = 31). b TUNEL staining for apoptosis on representative colonic crypts of mice with indicated genotype and treatment. Black bar, Wdr13 +/0 mice (n = 132); white bar, Wdr13 -/0 mice (n = 162); Dark grey bar, AOM/DSS-treated Wdr13 +/0 mice (n = 121); Light grey bar, AOM/DSS-treated Wdr13 -/0 mice (n = 93). n- Shows number of crypts counted for respective genotype. Scale bar, 20 μm, *- p <0.05

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BMC Cancer

ISSN: 1471-2407

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