Characterization of BRCA1 and BRCA2 variants in multi-ethnic Asian cohort from a Malaysian case-control study

BMC Cancer

Table 1 Characteristics of Malaysian breast cancer cases and healthy controls

Characteristics	Breast cancer cases		Healthy controls		p-value
	N = 2,110		N = 1,493
	N	%	N	%
Ethnicity					<0.001
Chinese	1,394	66.1	1,071	71.7
Malay	406	19.2	167	11.2
Indian	310	14.7	255	17.1
Age^a (years)
Average age	49.5		50.3		0.009
≤ 30	76	3.6	0	0
31–40	337	16.0	72	4.8
41–50	751	35.6	781	52.3
51–60	623	29.5	501	33.6
≥ 61	323	15.3	139	9.3
Family history^b					0.001
Yes	506	24.0	288	19.3
No	1,598	75.7	1,205	80.7
No data	6	0.3	0	0
Pathology profile
ER+	1,218	57.7
ER-	451	21.4
Triple negative	242	11.5
No data	199	9.4

^a Age of diagnosis for breast cancer cases or age of consent for healthy controls
^b Family history of breast or ovarian cancer in first or second degree relatives

ISSN: 1471-2407