Adipokines, insulin resistance, and adiposity as a predictors of metabolic syndrome in child survivors of lymphoma and acute lymphoblastic leukemia of a developing country

Barbosa-Cortés, Lourdes; López-Alarcón, Mardia; Mejía-Aranguré, Juan Manuel; Klünder-Klünder, Miguel; del Carmen Rodríguez-Zepeda, María; Rivera-Márquez, Hugo; de la Vega-Martínez, Alan; Martin-Trejo, Jorge; Shum-Luis, Juan; Solis-Labastida, Karina; López-Aguilar, Enrique; Matute-González, Guadalupe; Bernaldez-Rios, Roberto

doi:10.1186/s12885-017-3097-8

Table 5 Analysis of metabolic variables with the components of metabolic syndrome at first assessment

From: Adipokines, insulin resistance, and adiposity as a predictors of metabolic syndrome in child survivors of lymphoma and acute lymphoblastic leukemia of a developing country

Outcome variables	Fat percentage tertile (values)^a		HOMA-IR tertile ^a		Adiponectin tertile^a		Leptin tertile^a		Leptin adiponectin ratio tertile^a
Outcome variables	2 (24.2–35.0)	3 (35.1–46.7)	2 (3.6–5.5)	3 (5.6–13.9)	2 (15.3–25.4)	3 (25.5–44.3)	2 (4.1–13.4)	3 (13.5–30.8)	2 (0.3–0.7)	3 (0.8–2.9)
MS
Waist circumference (cm)
Coeficient	9.5	17.7	6.2	13.8	−1.9	−6.2	7.6	15.7	10.0	14.6
95% CI	3.4; 16.6	11.6; 23.7	−0.6; 13.1	6.9; 20.7	−10.1; 6.3	−14.4; 1.9	0.6; 14.6	8.7; 22.6	2.8; 17.1	7.4; 21.7
P	0.033	0.000	0.075	<0.001	0.641	0.133	0.033	<0.001	0.007	<0.001
Blood Pressure (mmHg)
Systolic BP
Coeficient	0.2	6.2	2.3	6.2	−1.4	−0.3	0.4375	5.4	3.1	7.6
95% CI	−6.4; 6.9	−0.5; 12.8	−4.4; 9.1	−0.4; 12.8	−8.3; 5.6	−7.4; 6.8	−6.4; 7.3	−1.4; 12.3	−3.6; 9.8	0.9; 14.3
P	0.944	0.068	0.488	0.066	0.693	0.940	0.898	0.117	0.353	0.027
Diastolic BP
Coeficient	1.3	6.1	1.0	3.6	2.3	1.9	1.8	5.9	2.3	5.4
95% CI	−4.0; 7.1	0.3; 11.8	−5.0; 6.9	−2.3; 9.4	−4.0; 8.5	−4.4; 8.3	−4.4; 7.9	−0.3; 12.0	−3.9; 8.5	−0.8; 11.6
P	0.654	0.040	0.745	0.227	0.473	0.542	0.570	0.061	0.470	0.088
Glucose (mg/dL)
Coeficient	4.9	0.1	4.9	10.6	−5.1	−0.6	4.2	2.3	1.3	2.9
95% CI	−0.8; 10.6	−5.6; 4.7	−0.1; 10.0	5.6; 15.7	−10.9; 0.8	−6.4; 5.2	−1.8; 10.1	−3.6; 8.3	−4.7; 7.3	−3.1; 8.9
P	0.089	0.983	0.055	<0.001	0.087	0.838	0.165	0.433	0.657	0.341
Triglycerides (mg/dL)
Coeficient	28.4	52.3	36.6	38.8	3.7	−23.1	14.2	56.7	31.7	56.4
95% CI	−2.9; 59.8	20.9; 83.7	4.1; 69.0	6.3; 71.3	−30.8; 38.1	−57.5; 11.4	−16.7; 45.0	25.8; 87.6	0.5; 62.9	25.2; 87.7
P	0.075	0.002	0.028	0.020	0.832	0.184	0.360	0.001	0.046	0.001
HDL-C (mg/dL)
Coeficient	−6.0	−3.0	−2.3	−8.2	−5.1	1.9	−1.1875	−4.9	−5.3	−9.4
95% CI	−14.5; 2.6	−11.6; 5.5	−10.6; 6.1	−16.6; 0.1	−13.2; 3.0	−6.2; 10.0	−9.4; 7.0	−13.1; 3.3	−13.2; 2.6	−17.3; −1.5
P	0.167	0.477	0.586	0.053	0.213	0.644	0.773	0.237	0.182	0.021
Adipokines
Adiponectin (μg/mL)
Coeficient	−4.6	4.3	0.3	−1.1			2.0	1.9	-	-
95% CI	−12.9; 3.8	−4.2; 12.8	−8.7; 9.3	−9.9; 7.8	-	-	−6.9; 10.8	−6.9; 10.7
P	0.274	0.317	0.950	0.809			0.656	0.667
Adiponectin (μg/mL/Kg)
Coeficient	−0.7	−0.5	−0.5	−1.7			−0.5	−1.0	-	-
95% CI	−2.1; 0.6	−1.8; 0.9	−1.8; 0.7	−2.9; −0.5	-	-	−1.9; 0.9	−2.3; 0.4
P	0.288	0.497	0.408	0.009			0.445	0.165
Leptin (μg/mL)
Coeficient	7.3	16.0	4.3	10.0	4.9	2.0	-		-	-
95% CI	4.6; 10.0	13.2; 18.8	−0.3; 9.0	5.4; 14.6	-0.3; 10.2	−3.2; 7.3
P	<0.001	<0.001	0.069	<0.001	0.067	0.441
Leptin (μg/mL/Kg)
Coeficient	0.6	1.0	0.7	0.3	0.7	0.1	-	-	-	-
95% CI	0.1; 1.2	0.4; 1.5	0.1; 1.3	−0.3; 0.9	0.1; 1.2	-0.4; 0.7
P	0.048	0.001	0.037	0.341	0.032	0.699
Insulin resistance
Fasting insulin (mμ/mL)
Coeficient	13.3	10.6	-	-	−2.2	−2.3	10.6	15.0	11.2	13.1
95% CI	7.0; 19.6	4.3; 16.9			−10.1; 5.6	−10.1; 5.5	4.2; 17.0	8.6; 21.4	4.6; 17.9	6.4; 19.8
P	<0.001	0.001			0.569	0.559	0.002	<0.001	0.001	<0.001
HOMA-IR
Coeficient	3.2	2.3	-	-	−0.8	−0.6	2.6	3.4	2.6	3.1
95% CI	1.6; 4.9	0.7; 3.9			−2.8; 1.1	−2.5; 1.3	0.9; 4.3	1.7; 5.1	0.9; 4.3	1.3; 4.8
P	<0.001	0.007			0.391	0.537	0.003	<0.001	0.004	0.001

Values obtained through robust linear regression analysis, adjusted for gender, age, treatment (only chemotherapy or chemotherapy plus radiotherapy), and diagnoses (acute lymphoblastic leukemia or lymphoma). ^aThe referent was tertile 1. Abbreviations: MS Metabolic syndrome

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