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HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation

  • Martin McLaughlin1Email author,
  • Holly E. Barker1,
  • Aadil A. Khan1,
  • Malin Pedersen1,
  • Magnus Dillon1,
  • David C. Mansfield1,
  • Radhika Patel1,
  • Joan N. Kyula1,
  • Shreerang A. Bhide2, 3,
  • Kate L. Newbold2, 3,
  • Christopher M. Nutting2, 3 and
  • Kevin J. Harrington1, 2, 3
BMC Cancer201717:86

Received: 3 August 2016

Accepted: 23 January 2017

Published: 31 January 2017

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
3 Aug 2016 Submitted Original manuscript
15 Oct 2016 Reviewed Reviewer Report - Tim Beck
21 Oct 2016 Reviewed Reviewer Report - Anna Gaponova
21 Dec 2016 Author responded Author comments - Martin McLaughlin
Resubmission - Version 2
21 Dec 2016 Submitted Manuscript version 2
23 Jan 2017 Editorially accepted
31 Jan 2017 Article published 10.1186/s12885-017-3084-0

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Targeted Therapy Team, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK
The Royal Marsden Hospital, London, UK
Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK