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Table 2 Associations of mammographic breast density with demographic and clinical variables

From: Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort

Characteristic

Low (N = 69, 15%)

Moderate (N = 231, 49%)

High (N = 170, 36%)

Total (N = 470)

p-valuea

Multivariate p-valueb

Age at Benign Biopsy

<0.001

0.001

  < 45

7 (10.1%)

15 (6.5%)

32 (18.8%)

54 (11.5%)

  

 45-55

9 (13.0%)

76 (32.9%)

67 (39.4%)

152 (32.3%)

  

 55+

53 (76.8%)

140 (60.6%)

71 (41.8%)

264 (56.2%)

  

Type of Density Measure

<0.001

<0.001

 BI-RADS

9 (13.0%)

140 (60.6%)

39 (22.9%)

188 (40.0%)

  

 PPAT

60 (87.0%)

91 (39.4%)

131 (77.1%)

282 (60.0%)

  

Number of Atypical Foci

0.31

 

 1

47 (68.1%)

126 (54.5%)

96 (56.5%)

269 (57.2%)

  

 2

15 (21.7%)

61 (26.4%)

42 (24.7%)

118 (25.1%)

  

 3+

7 (10.1%)

44 (19.0%)

32 (18.8%)

83 (17.7%)

  

Type of Atypia

0.004

0.11

 ADH

41 (59.4%)

116 (50.2%)

65 (38.2%)

222 (47.2%)

  

 ALH

27 (39.1%)

96 (41.6%)

96 (56.5%)

219 (46.6%)

  

 ADH and ALH

1 (1.4%)

19 (8.2%)

9 (5.3%)

29 (6.2%)

  

Involution

<0.001

0.03

 Missing

2

11

7

20

  

 None

1 (1.5%)

19 (8.6%)

26 (16.0%)

46 (10.2%)

  

 Partial

41 (61.2%)

124 (56.4%)

112 (68.7%)

277 (61.6%)

  

 Complete

25 (37.3%)

77 (35.0%)

25 (15.3%)

127 (28.2%)

  

BMI

<0.001

<0.001

 Missing

1

2

2

5

  

  < 25

25 (36.8%)

78 (34.1%)

101 (60.1%)

204 (43.9%)

  

 25-29

19 (27.9%)

70 (30.6%)

35 (20.8%)

124 (26.7%)

  

 30+

24 (35.3%)

81 (35.4%)

32 (19.0%)

137 (29.5%)

  
  1. Values presented as number (percent)
  2. a Chi-square tests
  3. b Multicategorical nominal logistic regression analysis modeling extent of density as the outcome variable. Model includes all variables found to be univariately significant (p < 0.05)