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Table 1 Inclusion and exclusion criteria

From: Study protocol of the TIRED study: a randomised controlled trial comparing either graded exercise therapy for severe fatigue or cognitive behaviour therapy with usual care in patients with incurable cancer

Inclusion criteria
(1) Age ≥ 18 years.
(2) Able to read, speak and write the Dutch language.
(3) Diagnosis of incurable cancer (i.e. breast, colorectal, prostate, renal cell, bladder, endometrial, ovarian, cervical, bone and soft tissue cancer, or melanoma).
(4) Scheduled for or receiving systemic cancer treatment with palliative intent (i.e., chemotherapy, and/or hormone therapy, and/or targeted therapy, and/or immunotherapy, possibly combined with surgery and/or radiotherapy).
(5) Cancer treatment plan based on an expected survival of ≥ 6 months as judged by their oncologist.
(6) Severely fatigued (CIS-fatigue score ≥ 35).
Exclusion criteria
(1) Treatable somatic cause that could explain the presence of severe fatigue (other than the underlying disease and the cancer treatment itself).
(2) Karnofsky Performance Status < 70.
(3) Symptomatic brain metastases.
(4) Severe cognitive problems.
(5) Not able to walk at least 6 min successively.
(6) Contra-indication for physical exercise.
(7) Current treatment by a psychiatrist or psychologist for a psychiatric disorder.