Fig. 5

Intranasal delivery of CCL2 increases the concentration of CCL2 in the lung. Daily intranasal delivery of increasing concentrations of CCL2 (0, 50, 100, 500 and 1000 ng) resulted in increasing concentrations of CCL2 in the lung with saturation achieved by the 500 ng delivery or 1000 ng delivery compared to 50 ng delivery (p = 0.016 and p = 0.015, respectively). Kruskal-Wallis test with Dunn’s test for multiple comparisons. Data are graphed as mean ± SD