Fig. 4

Two-dimensional phase contrast projection imaging of HCCLM3 liver xenografts at weeks 1 to 4. 1w-b and 2w-b are magnified images of the boxed regions in 1w-a and 2w-a, respectively. The red arrows indicate the margins of the tumor, in which the normal hepatic vascular structure was damaged and replaced. The dark region is the shadow from the suture. The vascular boundary enhancement in the tumor region was detected as low contrast in the quantitative analysis results (1w-c, 2w-c, 3w-b, 4w-b). Normal liver tissue presented as a thin edge with low contrast, close to the tumor tissue (3w-b, 4w-b)