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Table 6 Sample size in each group (n) and hazard ratios (HRs*) for selected scenarios of reduction in mortality by intervention. The power is 80% and significance level 5%

From: The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial

  Reduction in mortality by intervention Survival rates in the control group
Primary outcome 20% 25% 30%  
n (HR) n (HR) n (HR)  
DFS
5 years 320 (0.753) 190 (0.696) 140 (0.641) 0.59
10 years 240 (0.716) 140 (0.655) 110 (0.597) 0.41
15 years 180 (0.680) 120 (0.616) 90 (0.557) 0.29
OS
5 years 390 (0.767) 250 (0.712) 160 (0.658) 0.68
10 years 280 (0.732) 180 (0.673) 130 (0.616) 0.48
15 years 210 (0.695) 140 (0.632) 100 (0.574) 0.34
  1. * HR = hazard ratio of intervention versus control, which corresponds to the assumed survival rate in the control group and assumed reduction in mortality by intervention
  2. DFS disease-free survival, OS overall survival