Table 6 Sample size in each group (n) and hazard ratios (HRs*) for selected scenarios of reduction in mortality by intervention. The power is 80% and significance level 5%

Primary outcome

20%

25%

30%

n (HR)

n (HR)

n (HR)

5 years

320 (0.753)

190 (0.696)

140 (0.641)

0.59

10 years

240 (0.716)

140 (0.655)

110 (0.597)

0.41

15 years

180 (0.680)

120 (0.616)

90 (0.557)

0.29

5 years

390 (0.767)

250 (0.712)

160 (0.658)

0.68

10 years

280 (0.732)

180 (0.673)

130 (0.616)

0.48

15 years

210 (0.695)

140 (0.632)

100 (0.574)

0.34