Table 7 Cox regression analysis of CEA, CYFRA21-1 and NSE in different stages of lung cancer
Multivariate HR (95% CI) | P value | |
|---|---|---|
A I + II | ||
Age | ||
< 45 | 1[Reference] | 0.405 |
45–65 | 0.390 (0.043–3.577) | |
> 65 | 0.664 (0.075–5.874) | |
Sex | ||
Male 1[Reference] | 0.997 | |
Female | 0.998 (0.358–2.779) | |
Smokes | ||
No | 1[Reference] | 0.828 |
Yes | 1.091 (0.496–2.400) | |
Histological classification | ||
SCC | 1[Reference] | 0.400 |
ADC | 0.692 (0.294–1.631) | |
SCLC | 1.000 (0.347–2.884) | |
Unknown | 0.943 (0.242–3.670) | |
Metastasis | ||
No | 1[Reference] | 0.992 |
Yes | 0.997 (0.505–1.967) | |
CEA | ||
Neg | 1[Reference] | 0.483 |
Moderate | 1.213 (0.555–2.651) | |
High | 1.442 (0.519–4.009) | |
NSE | ||
Neg | 1[Reference] | 0.592 |
Moderate | 1.064 (0.542–2.090) | |
High | 0.718 (0.214–2.411) | |
CYFRA | ||
Neg | 1[Reference] | <0.05* |
Moderate | 1.696 (0.848–3.390) | |
High | 3.666 (1.095–12.279) | |
B. Stage III | ||
Age | ||
< 45 | 1[Reference] | 0.147 |
45–65 | 0.492 (0.189–1.283) | |
> 65 | 1.230 (0.491–3.083) | |
Sex | ||
Male | 1[Reference] | 0.934 |
Female | 0.976 (0.555–1.718) | |
Smokes | ||
No | 1[Reference] | 0.758 |
Yes | 1.075 (0.680–1.699) | |
Histological classification | ||
SCC | 1[Reference] | 0.272 |
ADC | 0.974 (0.624–1.521) | |
SCLC | 0.796 (0.445–1.424) | |
Unknown | 1.439 (0.752–2.756) | |
Metastasis | ||
No | 1[Reference] | 0.094 |
Yes | 1.444 (0.939–0.221) | |
CEA | ||
Neg | 1[Reference] | 0.423 |
Moderate | 1.047 (0.715–1.532) | |
High | 1.260 (0.716–2.218) | |
NSE | ||
Neg | 1[Reference] | 0.165 |
Moderate | 0.738 (0.480–1.134) | |
High | 1.333 (0.796–2.323) | |
CYFRA | ||
Neg | 1[Reference] | <0.05* |
Moderate | 1.279 (0.844–1.938) | |
High | 1.919 (1.200–3.071) | |
C Stage IV | ||
Age | ||
< 45 | 1[Reference] | 0.285 |
45–65 | 0.818 (0.566–1.182) | |
> 65 | 1.052 (0.739–1.499) | |
Sex | ||
Male | 1[Reference] | 0.452 |
Female | 1.125 (0.827–1.531) | |
Smokes | ||
No | 1[Reference] | 0.130 |
Yes | 1.261 (0.934–1.702) | |
Histological classification | ||
SCC | 1[Reference] | 0.090 |
ADC | 1.299 (0.960–1.756) | |
SCLC | 1.182 (0.801–1.744) | |
Unknown | 1.811 (1.082–3.030) | |
Metastasis | ||
No | 1[Reference] | <0.05* |
Yes | 1.494 (1.034–2.160) | |
CEA | ||
Neg | 1[Reference] | 0.332 |
Moderate | 1.132 (0.881–1.456) | |
High | 1.074 (0.802–1.439) | |
NSE | ||
Neg | 1[Reference] | 0.060 |
Moderate | 1.042 (0.806–1.346) | |
High | 1.319 (0.989–1.759) | |
CYFRA | ||
Neg | 1[Reference] | <0.05* |
Moderate | 1.107 (0.822–1.489) | |
High | 1.473 (1.056–2.053) | |