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Table 6 The multivariate analysis of different histological classifications

From: The important role of circulating CYFRA21-1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron-specific enolase in lung cancer patients

 

Adenocarcinoma

Squamous

SCLC

(n = 445)

(n = 215)

(n = 159)

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age

  < 45

1[Reference]

<0.05*

1[Reference]

<0.05*

1[Reference]

0.104

 45–65

0.733 (0.489–1.099)

 

0.866 (0.259–2.895)

 

0.769 (0.315–1.876)

  > 65

1.084 (0.741–1.587)

 

1.712 (0.523–5.607)

 

1.237 (0.510–3.003)

Sex

 Male

1[Reference]

0.338

1[Reference]

0.326

1[Reference]

0.354

 Female

0.986 (0.715–1.122)

 

1.312 (0.763–2.254)

 

0.758 (0.421–1.363)

Stages

 I + II

1[Reference]

0.415

1[Reference]

0.475

1[Reference]

0.902

 III + IV

1.703 (1.035–2.802)

 

0.832 (0.495–1.399)

 

1.091 (0.465–2.556)

Smoke status

 No

1[Reference]

0.177

1[Reference]

0.878

1[Reference]

0.076

 Yes

0.807 (0.592–1.102)

 

1.037 (0.651–1.651)

 

0.518 (0.251–1.071)

CEA levels

 Neg

1[Reference]

0.773

1[Reference]

0.295

1[Reference]

0.940

 Moderate

1.085 (0.679–1.736)

 

1.244 (0.620–2.497)

 

0.850 (0.317–2.280)

 High

1.169 (0.713–1.916)

 

0.700 (0.260–1.885)

 

0.894 (0.271–2.942)

CYFRA levels

 Neg

1[Reference]

<0.05*

1[Reference]

0.195

1[Reference]

<0.05*

 Moderate

1.161 (0.678–1.989)

 

1.057 (0.511–2.185)

 

1.365 (0.514–3.624)

 High

1.860 (1.036–3.338)

 

1.502 (0.673–3.353)

 

0.907 (0.285–2.880)

NSE levels

 Neg

1[Reference]

0.400

1[Reference]

0.329

1[Reference]

0.642

 Moderate

1.025 (0.727–1.446)

 

1.025 (0.727–1.446)

 

0.952 (0.390–2.323)

 High

1.154 (0.777–1.714)

 

1.154 (0.777–1.714)

 

1.342 (0.590–3.052)

Metastasis

 No

1[Reference]

0.477

1[Reference]

<0.05*

1[Reference]

<0.05*

 Yes

1.131 (0.806–1.585)

 

1.682 (1.052–2.688)

 

2.172 (1.180–3.998)

Positive numbers

 Neg

1[Reference]

0.852

1[Reference]

0.334

1[Reference]

0.814

 Single

1.334 (0.672–2.649)

 

0.748 (0.300–1.863)

 

2.107 (0.460–9.644)

 Double

1.491 (0.557–3.992)

 

1.115 (0.327–3.803)

 

2.247 (0.386–13.077)

 Triple

1.652 (0.517–5.276)

 

0.901 (0.183–4.449)

 

2.508 (0.231–27.287)