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Table 5 The multivariate analysis of lung cancer patients

From: The important role of circulating CYFRA21-1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron-specific enolase in lung cancer patients

 

Multivariate HR (95% CI)

P value

Age

  < 45

1[Reference]

<0.001*

 45–65

0.714 (0.513–0.994)

  > 65

1.089 (0.793–1.495)

Sex

 Male

1[Reference]

0.529

 Female

0.942 (0.782–1.135)

Histological classification

 Squamous

1[Reference]

<0.05*

 Adenocarcinoma

1.113 (0.894–1.384)

 SCLC

0.970 (0.729–1.290)

 Others

1.654 (1.160–2.358)

Stages

 I

1[Reference]

<0.05*

 II

1.096 (0.624–1.925)

 III

1.218 (0.753–1.969)

 IV

1.976 (1.120–3.488)

Smoke statues

 No

1[Reference]

0.095

 Yes

0.823 (0.655–1.035)

CEA levels

 Neg

1[Reference]

0.233

 Moderate

1.171 (0.954–1.438)

 High

1.217 (0.945–1.567)

CYFRA levels

 Neg

1[Reference]

<0.001*

 Moderate

1.226 (0.977–1.537)

 High

1.647 (1.273–2.130)

NSE levels

 Neg

1[Reference]

<0.05*

 Moderate

1.010 (0.808–1.263)

 High

1.330 (1.032–1.715)

Metastasis

 No

1[Reference]

<0.05*

 Yes

1.291 (1.025–1.625

Positive numbers

 Neg

1[Reference]

0.649

 Single

1.075 (0.806–1.434)

 Double

1.102 (0.898–1.353)

 Triple

1.086 (0.773–1.524)