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Table 4 The analysis of positive numbers of biomarkers in all lung cancer patients

From: The important role of circulating CYFRA21-1 in metastasis diagnosis and prognostic value compared with carcinoembryonic antigen and neuron-specific enolase in lung cancer patients

 

No. (%)

  

Neg

Single

Double

Triple

Total

P Value

 

(1–10 fold)

>10 fold

   

(n = 37)

(n = 101)

(n = 172)

(n = 122)

(n = 432)

 

Basic Characteristics

 Age

   < 45

2 (5.4)

5 (5.0)

12 (7.0)

9 (7.4)

28

0.057

  45-60

22 (59.5)

50 (49.5)

61 (35.5)

43 (35.2)

176

   > 60

13 (35.1)

46 (45.5)

99 (57.6)

70 (57.4)

228

 Sex

  Male

27 (73.0)

71 (70.3)

114 (66.3)

84 (68.9)

296

0.827

  Female

10 (27.0)

30 (29.7)

58 (33.7)

38 (31.1)

136

 Histological classification

  SCC

12 (32.4)

29 (28.7)

49 (28.5)

29 (23.8)

119

0.772

  ADC

19 (51.4)

53 (52.5)

90 (52.3)

63 (51.6)

225

  SCLC

3 (8.1)

12 (11.9)

24 (14)

24 (19.7)

63

  Others

3 (8.1)

7 (6.9)

9 (5.2)

6 (4.9)

25

 Stages

  I

5 (13.5)

8 (7.9)

5 (2.9)

0 (0)

18

<0.05*

  II

2 (5.4)

6 (5.9)

5 (2.9)

4 (3.3)

17

  III

14 (37.8)

34 (33.7)

43 (25)

37 (30.3)

128

  IV

14 (37.8)

47 (46.5)

109 (63.4)

73 (59.8)

243

  #Un.

2 (5.4)

6 (5.9)

10 (5.8)

8 (6.6)

26

 Smoke status

  No

16 (43.2)

54 (53.5)

73 (42.4)

48 (39.3)

191

0.178

  Yes

21 (56.8)

47 (46.5)

99 (57.6)

74 (60.7)

241

Metastasis

 Brain

  No

34 (91.9)

91 (90.1)

143 (83.1)

103 (84.4)

371

0.277

  Yes

3 (8.1)

10 (9.9)

29 (16.9)

19 (15.6)

61

 Bone

  No

33 (89.2)

87 (86.1)

127 (73.8)

88 (72.1)

335

<0.05*

  Yes

4 (10.8)

14 (13.9)

45 (26.2)

34 (27.9)

97

 Liver

  No

36 (97.3)

94 (93.1)

155 (90.1)

106 (86.9)

391

0.199

  Yes

1 (2.7)

7 (6.9)

17 (9.9)

16 (13.1)

41

 Adrenal gland

  No

36 (97.3)

98 (97)

154 (89.5)

117 (95.9)

405

0.086

  Yes

1 (1.7)

3 (3.0)

18 (10.5)

5 (4.1)

27

 Lymph node

  No

25 (67.6)

45 (44.6)

69 (40.1)

32 (26.2)

171

<0.001**

  Yes

12 (32.4)

56 (55.4)

103 (59.9)

90 (73.8)

261

 

 Intrapulmonary

  No

33 (89.2)

89 (88.1)

149 (86.6)

108 (88.5)

379

0.950

  Yes

4 (10.8)

12 (11.9)

23 (13.4)

14 (11.5)

53

 

 Pleural

  No

33 (89.2)

89 (88.1)

142 (82.6)

104 (85.2)

368

0.552

  Yes

4 (10.8)

12 (11.9)

30 (17.4)

18 (14.8)

64

 Mediastinal

  No

37 (100)

98 (97)

169 (98.3)

114 (93.4)

418

0.080

  Yes

0 (0.0)

3 (3.0)

3 (1.7)

8 (6.6)

14

 Peritoneum

  No

37 (100)

98 (93.7)

162 (94.2)

112 (91.8)

409

0.153

  Yes

0 (0.0)

3 (6.3)

10 (5.8)

10 (8.2)

23

 

Validation group

 

No. (%)

     

Neg

Single

Double

Triple

Total

P Value

(n = 27)

(n = 118)

(n = 161)

(n = 130)

(n = 436)

 

Basic Characteristics

 Age

  2 (7.4)

8 (6.8)

10 (6.2)

11 (8.5)

31

0.733

 

  10 (37.0)

46 (39.0)

48 (29.8)

45 (34.6)

149

  

  15 (55.6)

64 (54.2)

103 (64.0)

74 (56.9)

256

  

 Sex

  18 (66.7)

75 (63.6)

116 (72.0)

98 (75.4)

307

0.204

 

  9 (33.3)

43 (36.4)

45 (28.0)

32 (24.6)

129

  

 Histological classification

  7 (25.9)

31 (26.3)

37 (23)

21 (16.2)

96

0.386

 

  15 (55.6)

57 (48.3)

84 (52.2)

64 (49.2)

220

  

  1 (3.7)

5 (4.2)

11 (6.8)

7 (5.4)

24

  

  5 (18.5)

12 (10.2)

7 (4.3)

24 (18.5)

47

  

 Stages

  5 (18.5)

9 (7.6)

5 (3.1)

3 (2.3)

22

<0.05*

 

  5 (18.5)

16 (13.6)

10 (6.2)

7 (5.4)

38

  

  6 (22.2)

26 (22.0)

36 (22.4)

21 (16.2)

89

  

  11 (40.7)

58 (49.2)

103 (64.0)

90 (69.2)

262

  

  0 (0.0)

9 (7.6)

7 (4.3)

9 (19.2)

25

  

 Smoke status

  15 (55.6)

62 (52.5)

65 (40.4)

49 (37.7)

191

<0.05*

 

  12 (44.4)

56 (47.5)

96 (59.6)

81 (62.3)

245

  

Metastasis

 Brain

  27 (100.0)

107 (90.7)

134 (83.2)

110 (84.6)

378

<0.05*

 

  0 (0.0)

11 (9.3)

27 (16.8)

20 (15.4)

58

  

 Bone

  27 (100.0)

103 (87.3)

123 (76.4)

87 (66.9)

340

<0.001**

 

  0 (0.0)

15 (12.7)

38 (23.6)

43 (33.1)

96

  

 Liver

  No

26 (96.3)

111 (94.1)

140 (87.0)

106 (81.5)

383

<0.05*

  Yes

1 (3.7)

7 (5.9)

21 (13.0)

24 (18.5)

53

 

 Adrenal gland

  27 (100.0)

111 (94.1)

149 (92.5)

122 (93.8)

409

0.525

 

  0 (0.0)

7 (5.9)

12 (7.5)

8 (6.2)

27

  

 Lymph node

  19 (70.4)

58 (49.2)

50 (31.1)

40 (30.8)

167

<0.001***

 

  8 (29.6)

60 (50.8)

111 (68.9)

90 (69.2)

269

  

 Intrapulmonary

  26 (96.3)

105 (89.0)

130 (80.7)

114 (87.7)

375

0.064

 

  1 (3.7)

13 (11.0)

31 (19.3)

16 (12.3)

61

  

 Pleural

  25 (92.6)

107 (90.7)

129 (80.1)

104 (80.0)

365

<0.05*

 

  2 (7.4)

11 (9.3)

32 (20.8)

26 (20.0)

71

  

 Mediastinal

  27 (100.0)

116 (98.3)

152 (94.4)

123 (94.6)

418

0.229

 

  0 (0.0)

2 (1.7)

9 (5.6)

7 (5.4)

18

  

 Peritoneum

  27 (100.0)

110 (93.2)

144 (89.4)

118 (90.8)

399

0.269

 

  0 (0.0)

8 (6.8)

17 (10.4)

12 (9.2)

37