No. (%) | |||||
---|---|---|---|---|---|
Neg | Moderate | High | Total | P Value | |
1–3 fold | >3 fold | ||||
(n = 115) | (n = 190) | (n = 127) | (n = 432) | ||
Basic Characteristics | |||||
Age | |||||
< 45 | 5 (4.3) | 16 (8.4) | 7 (5.5) | 28 | 0.101 |
45–60 | 58 (50.4) | 72 (37.9) | 46 (36.2) | 176 | |
> 60 | 52 (45.3) | 102 (53.7) | 74 (58.3) | 228 | |
Sex | |||||
Male | 79 (68.7) | 134 (70.5) | 83 (65.4) | 296 | 0.623 |
Female | 36 (31.3) | 56 (29.5) | 44 (34.6) | 136 | |
Histological classification | |||||
SCC | 21 (18.3) | 42 (22.1) | 56 (44.1) | 119 | |
ADC | 64 (55.7) | 103 (54.2) | 58 (45.7) | 225 | <0.001** |
SCLC | 22 (19.1) | 34 (17.9) | 7 (5.5) | 63 | |
Others | 8 (6.9) | 11 (5.8) | 6 (4.7) | 25 | |
Stages | |||||
I | 12 (10.4) | 6 (3.2) | 0 (0.0) | 18 | <0.001** |
II | 7 (6.1) | 8 (4.2) | 2 (1.6) | 17 | |
III | 40 (34.8) | 50 (26.3) | 38 (29.9) | 128 | |
IV | 49 (42.6) | 115 (60.5) | 79 (62.2) | 243 | |
#Un. | 7 (6.1) | 11 (5.8) | 8 (6.3) | 26 | |
Smoke status | |||||
No | 55 (47.8) | 80 (42.1) | 56 (44.1) | 191 | 0.621 |
Yes | 60 (52.2) | 110 (57.9) | 71 (55.9) | 241 | |
Metastasis | |||||
Brain | |||||
No | 104 (90.4) | 162 (85.3) | 105 (82.7) | 371 | 0.212 |
Yes | 11 (9.6) | 28 (14.7) | 22 (17.3) | 61 | |
Bone | |||||
No | 101 (90.4) | 142 (74.7) | 92 (72.4) | 335 | <0.01** |
Yes | 14 (9.6) | 48 (25.3) | 35 (27.6) | 97 | |
Liver | |||||
No | 113 (98.3) | 170 (89.5) | 108 (85.0) | 391 | <0.01** |
Yes | 2 (1.7) | 20 (10.5) | 19 (15.0) | 41 | |
Adrenal gland | |||||
No | 113 (98.3) | 173 (91.1) | 119 (93.7) | 405 | <0.05* |
Yes | 2 (1.7) | 17 (8.9) | 8 (6.3) | 27 | |
Lymph node | |||||
No | 66 (57.4) | 68 (35.8) | 37 (29.1) | 171 | <0.001*** |
Yes | 49 (42.6) | 122 (64.2) | 90 (70.9) | 261 | |
Intrapulmonary | |||||
No | 105 (91.3) | 163 (85.8) | 111 (87.4) | 379 | 0.360 |
Yes | 21 (9.1) | 58 (14.9) | 35 (14.2) | 53 | |
Pleural | |||||
No | 100 (87.0) | 170 (89.5) | 98 (77.2) | 368 | <0.01** |
Yes | 15 (13.0) | 20 (10.5) | 29 (22.8) | 64 | |
Mediastinal | |||||
No | 113 (98.3) | 185 (97.4) | 120 (94.5) | 418 | 0.208 |
Yes | 2 (1.7) | 5 (2.6) | 7 (5.5) | 14 | |
Peritoneum | |||||
No | 115 (100) | 178 (93.7) | 116 (91.3) | 409 | <0.01** |
Yes | 0 (0.0) | 12 (6.3) | 11 (8.7) | 23 | |
Validation group | |||||
No. (%) | |||||
Neg | Moderate | High | Total | P Value | |
1–3 fold | >3 fold | ||||
(n = 116) | (n = 200) | (n = 120) | (n = 436) | ||
Basic Characteristics | |||||
Age | |||||
8 (6.9) | 13 (6.5) | 10 (8.3) | 31 | 0.073 | |
52 (44.8) | 61 (30.5) | 36 (30.0) | 149 | ||
56 (48.3) | 126 (63.0) | 74 (61.7) | 256 | ||
Sex | |||||
74 (63.8) | 139 (69.5) | 94 (78.3) | 307 | <0.05* | |
42 (36.2) | 61 (30.5) | 26 (21.7) | 129 | ||
Histological classification | |||||
15 (12.9) | 43 (21.5) | 38 (31.7) | 96 | <0.001** | |
56 (48.3) | 98 (49.0) | 66 (55.0) | 220 | ||
40 (34.5) | 47 (23.5) | 9 (7.5) | 96 | ||
5 (4.3) | 12 (6.0) | 7 (5.8) | 24 | ||
Stages | |||||
9 (7.8) | 9 (4.5) | 4 (3.3) | 22 | <0.05* | |
15 (12.9) | 20 (10.0) | 3 (2.5) | 38 | ||
23 (19.8) | 43 (21.5) | 23 (19.2) | 89 | ||
61 (52.6) | 115 (57.5) | 86 (71.7) | 262 | ||
8 (6.9) | 13 (6.5) | 4 (3.3) | 25 | ||
Smoke status | |||||
63 (54.3) | 86 (43.0) | 42 (35.0) | 191 | <0.05* | |
53 (45.7) | 114 (57.0) | 78 (65.0) | 245 | ||
Metastasis | |||||
Brain | |||||
102 (87.9) | 183 (91.5) | 93 (77.5) | 378 | <0.01** | |
14 (12.1) | 17 (8.5) | 27 (22.5) | 58 | ||
Bone | |||||
101 (87.1) | 160 (80.0) | 79 (65.8) | 340 | <0.001*** | |
15 (12.9) | 40 (20.0) | 41 (34.2) | 96 | ||
Liver | |||||
110 (94.8) | 177 (88.5) | 96 (80.0) | 383 | <0.01** | |
6 (5.2) | 23 (11.5) | 24 (20.0) | 53 | ||
Adrenal gland | |||||
107 (92.2) | 192 (96.0) | 110 (91.7) | 409 | 0.213 | |
9 (7.8) | 8 (4.0) | 10 (8.3) | 27 | ||
Lymph node | |||||
58 (50.0) | 68 (34.0) | 41 (34.2) | 167 | <0.01** | |
58 (50.0) | 132 (66.0) | 79 (65.8) | 269 | ||
Intrapulmonary | |||||
105 (90.5) | 169 (84.5) | 101 (84.2) | 375 | 0.262 | |
11 (9.5) | 31 (15.5) | 19 (15.8) | 61 | ||
Pleural | |||||
107 (92.2) | 168 (81.5) | 95 (79.2) | 365 | <0.05* | |
9 (7.8) | 37 (18.5) | 25 (20.8) | 71 | ||
Mediastinal | |||||
114 (98.3) | 192 (96.0) | 112 (93.3) | 418 | 0.161 | |
2 (1.7) | 8 (4.0) | 8 (6.7) | 18 | ||
Peritoneum | |||||
111 (95.7) | 189 (94.5) | 99 (82.5) | 399 | <0.01** | |
5 (4.3) | 11 (5.5) | 21 (17.5) | 37 |