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Table 1 Clinical characteristics of patients according to tumoral CCR7 expression

From: Prognostic value of CC-chemokine receptor seven expression in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitor

Characteristics Patients Tumoral CCR7 expression
n % low high P-value
No. of patients 110 100 53 57  
Age, years, mean (SD) 57.5 (11.9)    
Men 79 71.8    
ECOG PS 0.198c
 0 81 73.6 42 39  
 1 29 26.4 11 18  
Prior nephrectomy N/A
 Yes 110 100.0    
 No 0 0.0    
Histology 0.086c
 Clear cell 88 80.0 46 42  
 Non-clear cell type 22 20.0 7 15  
  Papillary 15 13.6    
  Chromophobe 2 1.8    
  Collecting duct 2 1.8    
  Unclassified 3 2.7    
Fuhrman grade (7 excluded) 0.147d
 1 2 1.8 2 0  
 2 53 48.2 28 25  
 3 41 37.3 18 23  
 4 7 6.4 5 2  
TNM stage at initial diagnosis 0.004 c
 I-III 51 46.4 32 19  
 IV 59 53.6 21 38  
Site of metastatic diseasea  
 Lung 82 74.5    
 Liver 13 11.8    
 Bone 18 16.4    
 Lymph node 29 26.4    
 Adrenal gland 8 7.3    
 Brain and others 15 13.6    
Lymph node involvementa 0.031 c
 No 81 73.6 44 37  
 Yes 29 26.4 9 20  
No. of metastatic sitesa 0.070c
 1 76 69.1 41 35  
  ≥ 2 34 30.9 12 22  
Tyrosine kinase inhibitors 0.254c
 Sunitinib 73 66.4 38 35  
 Sorafenib 37 33.6 15 22  
Heng’s risk group      0.271d
 Favorable 22 20 12 10  
 Intermediate 60 54.5 30 30  
 Poor 28 25.5 11 17  
Best response (3 not assessable) <0.001 d
 Partial response 27 25.2 18 9  
 Stable disease for ≥3 months 57 53.3 30 27  
 Progressive diseaseb 23 21.5 2 21  
  1. Bold data means statistical significant (P<0.05)
  2. SD standard deviation, ECOG PS Eastern Cooperative Oncology Group performance status
  3. P-value < 0.05 was regarded as statistically significant
  4. aAt the time initializing tyrosine kinase inhibitors
  5. bIncluding stable disease for <3 months
  6. cχ2 test or Fisher’s exact test
  7. dCochran-Mantel-Haenszel χ 2 test