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Table 4 Association of total calcium and vitamin D intake with prostate cancer in stratified analysis based on body mass index

From: Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

  Controls   Cases vs. Controls   High Risk vs. Controls   Gleason Score ≥4 + 3 vs. Controls
Unadjusted Adjusted Unadjusted Adjusted Unadjusted Adjusted
  n (%) n (%) OR (95% C.I.) OR (95% C.I.) n (%) OR (95% C.I.) OR (95% C.I.) n (%) OR (95% C.I.) OR (95% C.I.)
Total Calcium, mg/day
 BMI < Median (27.8)
  Quartile 1 (<368.8) 93 (21.5) 90 (25.9) 1.00 1.00 15 (18.8) 1.00 1.00 13 (18.1) 1.00 1.00
  Quartile 2 (368.8–616.0) 124 (28.7) 73 (21.6) 0.63 (0.42–0.94) 0.76 (0.47–1.24) 21 (26.3) 1.05 (0.51–2.15) 1.82 (0.74–4.43) 19 (26.4) 1.10 (0.52–2.33) 1.46 (0.60–3.54)
  Quartile 3 (616.1–1033.3) 110 (25.5) 92 (26.4) 0.86 (0.58–1.29) 1.06 (0.64–1.75) 18 (22.5) 1.02 (0.49–2.12) 1.25 (0.48–3.25) 19 (26.4) 1.24 (0.58–2.64) 1.57 (0.64–3.90)
  Quartile 4 (>1033.3) 105 (24.3) 91 (26.1) 0.90 (0.60–1.34) 1.13 (0.67–1.92) 26 (32.5) 1.54 (0.77–3.07) 3.43 (1.25–9.42) 21 (29.2) 1.43 (0.68–3.02) 2.69 (1.02–7.11)
  P for Trend    0.80 0.36   0.17 0.02   0.30 0.045
 BMI ≥ Median (27.8)
  Quartile 1 (<368.8) 127 (27.2) 80 (24.0) 1.00 1.00 17 (24.3) 1.00 1.00 15 (19.5) 1.00 1.00
  Quartile 2 (368.8–616.0) 109 (23.3) 85 (25.4) 1.24 (0.83–1.84) 1.18 (0.74–1.86) 11 (15.7) 0.75 (0.34–1.68) 0.79 (0.32–1.96) 13 (16.9) 1.01 (0.46–2.22) 1.02 (0.44–2.41)
  Quartile 3 (616.1–1033.3) 112 (24.0) 87 (26.0) 1.23 (0.83–1.83) 1.38 (0.85–2.23) 19 (27.1) 1.28 (0.63–2.56) 1.77 (0.71–4.42) 23 (29.9) 1.74 (0.87–3.50) 1.96 (0.85–4.53)
  Quartile 4 (>1033.3) 119 (25.5) 82 (24.6) 1.09 (0.74–1.63) 0.99 (0.60–1.67) 23 (32.9) 1.44 (0.74–2.84) 1.48 (0.56–3.91) 26 (33.8) 1.85 (0.93–3.66) 1.47 (0.61–3.55)
  P for Trend    0.81 0.78   0.14 0.32   0.04 0.32
   P for Interaction (Total Calcium Intake x BMI)     0.35    0.05    0.40
Total Vitamin D, IU/day
 BMI < Median (27.8)
  Quartile 1 (<63.5) 87 (20.1) 89 (25.6) 1.00 1.00 18 (22.5) 1.00 1.00 18 (25.0) 1.00 1.00
  Quartile 2 (63.5–239.2) 109 (25.2) 90 (25.9) 0.81 (0.54–1.21) 0.85 (0.52–1.41) 20 (25.0) 0.89 (0.44–1.78) 0.86 (0.35–2.07) 18 (25.0) 0.80 (0.39–1.63) 0.78 (0.33–1.84)
  Quartile 3 (239.3–510.2) 106 (24.5) 95 (27.3) 0.88 (0.58–1.31) 0.89 (0.54–1.48) 35 (43.8) 1.60 (0.85–3.01) 1.28 (0.54–3.03) 27 (37.5) 1.23 (0.64–2.38) 1.06 (0.46–2.43)
  Quartile 4 (>510.2) 130 (30.1) 74 (21.3) 0.56 (0.37–0.84) 0.57 (0.33–0.97) 7 (8.8) 0.26 (0.10–0.65) 0.09 (0.02–0.35) 9 (12.5) 0.34 (0.14–0.78) 0.20 (0.07–0.60)
  P for Trend    0.009 0.03   0.009 0.001   0.02 0.004
 BMI ≥ Median (27.8)
 Total Vitamin D, IU/day
  Quartile 1 (<63.5) 125 (26.8) 88 (26.3) 1.00 1.00 18 (25.7) 1.00 1.00 15 (19.5) 1.00 1.00
  Quartile 2 (63.5–239.2) 115 (24.6) 80 (24.0) 0.99 (0.67–1.47) 0.87 (0.54–1.40) 19 (27.1) 1.15 (0.57–2.29) 0.82 (0.33–2.02) 20 (26.0) 1.45 (0.71–2.97) 1.02 (0.43–2.40)
  Quartile 3 (239.3–510.2) 117 (25.1) 72 (21.6) 0.87 (0.59–1.31) 0.88 (0.54–1.42) 14 (20.0) 0.83 (0.40–1.75) 0.73 (0.29–1.84) 16 (20.8) 1.14 (0.54–2.41) 1.07 (0.45–2.53)
  Quartile 4 (>510.2) 110 (23.6) 94 (28.1) 1.21 (0.83–1.79) 1.16 (0.71–1.90) 19 (27.1) 1.20 (0.60–2.40) 0.81 (0.31–2.12) 26 (33.8) 1.97 (0.99–3.91) 1.37 (0.57–3.28)
  P for Trend    0.30 0.34   0.75 0.78   0.08 0.38
   P for Interaction (Total Vitamin D Intake x BMI)     0.12    0.02    0.04
  1. NOTE: Model adjusted for age, family history of PCa, race/ethnicity, education, smoking, alcohol use, and marital status as well as mutually adjustment for total calcium or vitamin D intake. Significant association is shown with bolded type