Table 4 Association of total calcium and vitamin D intake with prostate cancer in stratified analysis based on body mass index
From: Race and BMI modify associations of calcium and vitamin D intake with prostate cancer
|  | Controls |  | Cases vs. Controls |  | High Risk vs. Controls |  | Gleason Score ≥4 + 3 vs. Controls | |||
|---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | |||||
| Â | n (%) | n (%) | OR (95% C.I.) | OR (95% C.I.) | n (%) | OR (95% C.I.) | OR (95% C.I.) | n (%) | OR (95% C.I.) | OR (95% C.I.) |
Total Calcium, mg/day | ||||||||||
 BMI < Median (27.8) | ||||||||||
  Quartile 1 (<368.8) | 93 (21.5) | 90 (25.9) | 1.00 | 1.00 | 15 (18.8) | 1.00 | 1.00 | 13 (18.1) | 1.00 | 1.00 |
  Quartile 2 (368.8–616.0) | 124 (28.7) | 73 (21.6) | 0.63 (0.42–0.94) | 0.76 (0.47–1.24) | 21 (26.3) | 1.05 (0.51–2.15) | 1.82 (0.74–4.43) | 19 (26.4) | 1.10 (0.52–2.33) | 1.46 (0.60–3.54) |
  Quartile 3 (616.1–1033.3) | 110 (25.5) | 92 (26.4) | 0.86 (0.58–1.29) | 1.06 (0.64–1.75) | 18 (22.5) | 1.02 (0.49–2.12) | 1.25 (0.48–3.25) | 19 (26.4) | 1.24 (0.58–2.64) | 1.57 (0.64–3.90) |
  Quartile 4 (>1033.3) | 105 (24.3) | 91 (26.1) | 0.90 (0.60–1.34) | 1.13 (0.67–1.92) | 26 (32.5) | 1.54 (0.77–3.07) | 3.43 (1.25–9.42) | 21 (29.2) | 1.43 (0.68–3.02) | 2.69 (1.02–7.11) |
  P for Trend |  |  | 0.80 | 0.36 |  | 0.17 | 0.02 |  | 0.30 | 0.045 |
 BMI ≥ Median (27.8) | ||||||||||
  Quartile 1 (<368.8) | 127 (27.2) | 80 (24.0) | 1.00 | 1.00 | 17 (24.3) | 1.00 | 1.00 | 15 (19.5) | 1.00 | 1.00 |
  Quartile 2 (368.8–616.0) | 109 (23.3) | 85 (25.4) | 1.24 (0.83–1.84) | 1.18 (0.74–1.86) | 11 (15.7) | 0.75 (0.34–1.68) | 0.79 (0.32–1.96) | 13 (16.9) | 1.01 (0.46–2.22) | 1.02 (0.44–2.41) |
  Quartile 3 (616.1–1033.3) | 112 (24.0) | 87 (26.0) | 1.23 (0.83–1.83) | 1.38 (0.85–2.23) | 19 (27.1) | 1.28 (0.63–2.56) | 1.77 (0.71–4.42) | 23 (29.9) | 1.74 (0.87–3.50) | 1.96 (0.85–4.53) |
  Quartile 4 (>1033.3) | 119 (25.5) | 82 (24.6) | 1.09 (0.74–1.63) | 0.99 (0.60–1.67) | 23 (32.9) | 1.44 (0.74–2.84) | 1.48 (0.56–3.91) | 26 (33.8) | 1.85 (0.93–3.66) | 1.47 (0.61–3.55) |
  P for Trend |  |  | 0.81 | 0.78 |  | 0.14 | 0.32 |  | 0.04 | 0.32 |
   P for Interaction (Total Calcium Intake x BMI) |  |  |  | 0.35 |  |  | 0.05 |  |  | 0.40 |
Total Vitamin D, IU/day | ||||||||||
 BMI < Median (27.8) | ||||||||||
  Quartile 1 (<63.5) | 87 (20.1) | 89 (25.6) | 1.00 | 1.00 | 18 (22.5) | 1.00 | 1.00 | 18 (25.0) | 1.00 | 1.00 |
  Quartile 2 (63.5–239.2) | 109 (25.2) | 90 (25.9) | 0.81 (0.54–1.21) | 0.85 (0.52–1.41) | 20 (25.0) | 0.89 (0.44–1.78) | 0.86 (0.35–2.07) | 18 (25.0) | 0.80 (0.39–1.63) | 0.78 (0.33–1.84) |
  Quartile 3 (239.3–510.2) | 106 (24.5) | 95 (27.3) | 0.88 (0.58–1.31) | 0.89 (0.54–1.48) | 35 (43.8) | 1.60 (0.85–3.01) | 1.28 (0.54–3.03) | 27 (37.5) | 1.23 (0.64–2.38) | 1.06 (0.46–2.43) |
  Quartile 4 (>510.2) | 130 (30.1) | 74 (21.3) | 0.56 (0.37–0.84) | 0.57 (0.33–0.97) | 7 (8.8) | 0.26 (0.10–0.65) | 0.09 (0.02–0.35) | 9 (12.5) | 0.34 (0.14–0.78) | 0.20 (0.07–0.60) |
  P for Trend |  |  | 0.009 | 0.03 |  | 0.009 | 0.001 |  | 0.02 | 0.004 |
 BMI ≥ Median (27.8) | ||||||||||
 Total Vitamin D, IU/day | ||||||||||
  Quartile 1 (<63.5) | 125 (26.8) | 88 (26.3) | 1.00 | 1.00 | 18 (25.7) | 1.00 | 1.00 | 15 (19.5) | 1.00 | 1.00 |
  Quartile 2 (63.5–239.2) | 115 (24.6) | 80 (24.0) | 0.99 (0.67–1.47) | 0.87 (0.54–1.40) | 19 (27.1) | 1.15 (0.57–2.29) | 0.82 (0.33–2.02) | 20 (26.0) | 1.45 (0.71–2.97) | 1.02 (0.43–2.40) |
  Quartile 3 (239.3–510.2) | 117 (25.1) | 72 (21.6) | 0.87 (0.59–1.31) | 0.88 (0.54–1.42) | 14 (20.0) | 0.83 (0.40–1.75) | 0.73 (0.29–1.84) | 16 (20.8) | 1.14 (0.54–2.41) | 1.07 (0.45–2.53) |
  Quartile 4 (>510.2) | 110 (23.6) | 94 (28.1) | 1.21 (0.83–1.79) | 1.16 (0.71–1.90) | 19 (27.1) | 1.20 (0.60–2.40) | 0.81 (0.31–2.12) | 26 (33.8) | 1.97 (0.99–3.91) | 1.37 (0.57–3.28) |
  P for Trend |  |  | 0.30 | 0.34 |  | 0.75 | 0.78 |  | 0.08 | 0.38 |
   P for Interaction (Total Vitamin D Intake x BMI) |  |  |  | 0.12 |  |  | 0.02 |  |  | 0.04 |