Skip to main content

Table 3 Association of total calcium and vitamin D intake with prostate cancer in African Americans and European Americans

From: Race and BMI modify associations of calcium and vitamin D intake with prostate cancer

  Controls   Cases vs. Controls   High Risk vs. Controls   Gleason Score ≥4 + 3 vs. Controls
Unadjusted Adjusted Unadjusted Adjusted Unadjusted Adjusted
  n (%) n (%) OR (95% C.I.) OR (95% C.I.) n (%) OR (95% C.I.) OR (95% C.I.) n (%) OR (95% C.I.) OR (95% C.I.)
Total Calcium, mg/day
 African Americans
  Quartile 1 (<368.8) 143 (28.8) 111 (28.4) 1.00 1.00 25 (23.8) 1.00 1.00 18 (21.7) 1.00 1.00
  Quartile 2 (368.8–616.0) 113 (22.7) 90 (23.0) 1.03 (0.71–1.49) 0.94 (0.61–1.58) 21 (20.0) 1.06 (0.57–2.00) 1.39 (0.63–3.09) 17 (20.5) 1.20 (0.59–2.42) 1.47 (0.62–3.51)
  Quartile 3 (616.1–1033.3) 123 (24.7) 91 (23.3) 0.95 (0.66–1.38) 1.20 (0.73–1.97) 24 (22.9) 1.12 (0.61–2.05) 1.88 (0.81–4.37) 23 (27.7) 1.49 (0.77–2.88) 2.32 (0.98–5.51)
  Quartile 4 (>1033.3) 118 (23.7) 99 (25.3) 1.08 (0.75–1.56) 1.33 (0.78–2.26) 35 (33.3) 1.70 (0.96–3.00) 4.28 (1.70–10.80) 25 (30.1) 1.68 (0.88–3.23) 3.42 (1.30–9.00)
  P for Trend    0.73 0.28   0.05 0.001   0.10 0.01
 European Americans
  Quartile 1 (<368.8) 80 (21.2) 54 (22.3) 1.00 1.00 5 (14.3) 1.00 1.00 9 (15.5) 1.00 1.00
  Quartile 2 (368.8–616.0) 115 (30.4) 60 (24.8) 0.77 (0.49–1.23) 0.84 (0.50–1.40) 10 (28.6) 1.39 (0.46–4.23) 1.66 (0.50–5.52) 15 (25.9) 1.16 (0.48–2.78) 1.27 (0.50–3.22)
  Quartile 3 (616.1–1033.3) 87 (23.0) 72 (29.8) 1.23 (0.77–1.95) 1.19 (0.70–2.03) 8 (22.9) 1.47 (0.46–4.68) 1.63 (0.43–6.18) 16 (27.6) 1.64 (0.68–3.91) 1.05 (0.41–2.68)
  Quartile 4 (>1033.3) 96 (25.4) 56 (23.1) 0.86 (0.54–1.39) 0.81 (0.46–1.43) 12 (34.3) 2.00 (0.68–5.92) 1.65 (0.44–6.16) 18 (31.0) 1.67 (0.71–3.91) 1.23 (0.48–3.11)
  P for Trend    0.98 0.54   0.20 0.88   0.18 0.54
   P for Interaction (Total Calcium Intake x Race)     0.70    0.99    0.99
Total Vitamin D, IU/day
 African Americans
  Quartile 1 (<63.5) 120 (24.1) 165 (23.6) 1.00 1.00 29 (27.6) 1.00 1.00 23 (27.7) 1.00 1.00
  Quartile 2 (63.5–239.2) 139 (28.0) 170 (24.3) 0.87 (0.61–1.25) 0.83 (0.51–1.34) 29 (27.6) 0.86 (0.49–1.53) 0.57 (0.26–1.24) 22 (26.5) 0.83 (0.44–1.56) 0.54 (0.24–1.25)
  Quartile 3 (239.3–510.2) 135 (27.2) 186 (26.6) 0.80 (0.56–1.15) 0.74 (0.45–1.21) 37 (35.2) 1.13 (0.66–1.96) 0.58 (0.26–1.27) 28 (33.7) 1.08 (0.59–1.98) 0.69 (0.31–1.55)
  Quartile 4 (>510.2) 103 (20.7) 178 (25.5) 0.71 (0.48–1.07) 0.53 (0.30–0.94) 10 (9.5) 0.40 (0.19–0.86) 0.06 (0.02–0.21) 10 (12.0) 0.51 (0.23–1.11) 0.17 (0.06–0.54)
  P for Trend    0.11 0.03   0.05 <0.001   0.18 0.008
 European Americans
  Quartile 1 (<63.5) 88 (23.3) 56 (23.1) 1.00 1.00 9 (25.7) 1.00 1.00 12 (20.7) 1.00 1.00
  Quartile 2 (63.5–239.2) 81 (21.4) 44 (18.2) 0.85 (0.52–1.40) 0.82 (0.47–1.44) 3 (8.6) 0.36 (0.10–1.38) 0.24 (0.05–1.11) 11 (19.0) 1.00 (0.42–2.38) 0.72 (0.27–1.93)
  Quartile 3 (239.3–510.2) 89 (23.5) 57 (23.6) 1.01 (0.63–1.61) 1.09 (0.63–1.87) 10 (28.6) 1.10 (0.43–2.83) 1.08 (0.34–3.44) 14 (24.1) 1.15 (0.51–2.63) 1.05 (0.41–2.68)
  Quartile 4 (>510.2) 120 (31.7) 85 (35.1) 1.11 (0.72–1.72) 1.25 (0.74–2.12) 13 (37.1) 1.06 (0.43–2.59) 1.32 (0.40–4.33) 21 (36.2) 1.28 (0.60–2.75) 1.23 (0.48–3.11)
  P for Trend    0.37 0.14   0.39 0.15   0.44 0.36
   P for Interaction (Total Vitamin D Intake x Race)     0.23    0.007    0.14
  1. NOTE: Model adjusted for age, family history of PCa, BMI, education, smoking, alcohol use, and marital status as well as mutually adjustment for total calcium or vitamin D intake. Significant association is shown with bolded type